Detalles de la búsqueda
1.
Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.
Drug Metab Dispos
; 2024 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38378703
2.
Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors .
J Pharmacol Exp Ther
; 384(1): 173-186, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36310034
3.
Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes.
Mol Pharm
; 19(1): 172-187, 2022 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34890209
4.
Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization.
Anal Biochem
; 568: 78-88, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30408457
5.
Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.
J Pharmacol Exp Ther
; 362(1): 108-118, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28465372
6.
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg Med Chem Lett
; 27(6): 1478-1483, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28190634
7.
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Bioorg Med Chem Lett
; 26(19): 4824-4828, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27554445
8.
Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans.
Xenobiotica
; 46(8): 667-76, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26586447
9.
Development of a Practical Nomogram for Personalized Anemia Management in Patients Treated with Ataxia Telangiectasia and Rad3-related Inhibitor Camonsertib.
Clin Cancer Res
; 30(4): 687-694, 2024 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38078898
10.
ATR inhibitor, camonsertib, dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study).
J Natl Cancer Inst
; 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38710487
11.
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results.
Nat Med
; 29(6): 1400-1411, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37277454
12.
Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.
Drug Metab Dispos
; 39(11): 2085-92, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21835977
13.
Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.
Drug Metab Dispos
; 39(3): 373-82, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21148079
14.
Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: anticipated thyroid effects and unique pituitary gland findings.
Toxicol Pathol
; 39(4): 664-77, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21551028
15.
Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible.
Biopharm Drug Dispos
; 32(5): 261-75, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21660978
16.
Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.
Cancer Chemother Pharmacol
; 88(3): 451-464, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34080039
17.
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Drug Metab Dispos
; 38(11): 1954-61, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20693416
18.
The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.
Xenobiotica
; 40(8): 536-46, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20528624
19.
Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades.
Trends Pharmacol Sci
; 41(6): 390-408, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32359836
20.
Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy.
Curr Drug Metab
; 21(2): 145-162, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32164508