Detalles de la búsqueda
1.
Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.
Drug Metab Dispos
; 2024 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38378703
2.
Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes.
Mol Pharm
; 19(1): 172-187, 2022 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34890209
3.
Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization.
Anal Biochem
; 568: 78-88, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30408457
4.
Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.
J Pharmacol Exp Ther
; 362(1): 108-118, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28465372
5.
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Bioorg Med Chem Lett
; 26(19): 4824-4828, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27554445
6.
Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans.
Xenobiotica
; 46(8): 667-76, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26586447
7.
Development of a Practical Nomogram for Personalized Anemia Management in Patients Treated with Ataxia Telangiectasia and Rad3-related Inhibitor Camonsertib.
Clin Cancer Res
; 30(4): 687-694, 2024 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38078898
8.
ATR inhibitor, camonsertib, dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study).
J Natl Cancer Inst
; 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38710487
9.
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results.
Nat Med
; 29(6): 1400-1411, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37277454
10.
Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.
Drug Metab Dispos
; 39(11): 2085-92, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21835977
11.
Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.
Drug Metab Dispos
; 39(3): 373-82, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21148079
12.
Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: anticipated thyroid effects and unique pituitary gland findings.
Toxicol Pathol
; 39(4): 664-77, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21551028
13.
Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.
Cancer Chemother Pharmacol
; 88(3): 451-464, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34080039
14.
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Drug Metab Dispos
; 38(11): 1954-61, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20693416
15.
The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.
Xenobiotica
; 40(8): 536-46, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20528624
16.
Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades.
Trends Pharmacol Sci
; 41(6): 390-408, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32359836
17.
Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl-1 Inhibitor AZD5991.
CPT Pharmacometrics Syst Pharmacol
; 9(10): 561-570, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32860732
18.
Sustained release and improved bioavailability in mice after subcutaneous administration of griseofulvin as nano- and microcrystals.
Int J Pharm
; 566: 565-572, 2019 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31181305
19.
Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.
Pharmacogenetics
; 12(2): 145-50, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11875368
20.
Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.
J Clin Pharmacol
; 42(6): 613-9, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12043950