Detalles de la búsqueda
1.
Direct antiproliferative effect of nonsteroidal 17ß-hydroxysteroid dehydrogenase type 1 inhibitors in vitro.
J Enzyme Inhib Med Chem
; 28(4): 695-703, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22471733
2.
Potent Dual Inhibitors of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.
J Med Chem
; 66(13): 8975-8992, 2023 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37369108
3.
Synthesis and biological evaluation of phenyl substituted 1H-1,2,4-triazoles as non-steroidal inhibitors of 17ß-hydroxysteroid dehydrogenase type 2.
Arch Pharm (Weinheim)
; 345(8): 610-21, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22532378
4.
Dual Targeting of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.
J Med Chem
; 65(17): 11726-11744, 2022 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35993890
5.
17ß-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
ACS Med Chem Lett
; 12(12): 1920-1924, 2021 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34917255
6.
Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Bioorg Med Chem
; 18(10): 3494-505, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20413314
7.
A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of Their Estrogenicity.
Mol Nutr Food Res
; 64(16): e2000289, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32640069
8.
Development of a biological screening system for the evaluation of highly active and selective 17beta-HSD1-inhibitors as potential therapeutic agents.
Mol Cell Endocrinol
; 301(1-2): 154-7, 2009 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18984028
9.
Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors.
Mol Cell Endocrinol
; 301(1-2): 205-11, 2009 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18950679
10.
The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2.
Mol Cell Endocrinol
; 301(1-2): 212-5, 2009 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18848601
11.
Inhibitors of 17ß-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.
Mol Cell Endocrinol
; 489: 66-81, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30336189
12.
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17ß-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.
Eur J Med Chem
; 178: 93-107, 2019 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31176098
13.
Design, Synthesis, and Biological Characterization of Orally Active 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
J Med Chem
; 62(15): 7289-7301, 2019 08 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31343176
14.
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
J Med Chem
; 62(3): 1362-1372, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30645111
15.
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
J Med Chem
; 51(7): 2158-69, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324762
16.
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Bioorg Med Chem
; 16(12): 6423-35, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18514529
17.
Highly Potent 17ß-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.
J Med Chem
; 61(23): 10724-10738, 2018 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30480443
18.
Structure-based design and profiling of novel 17ß-HSD14 inhibitors.
Eur J Med Chem
; 155: 61-76, 2018 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29859505
19.
First Dual Inhibitors of Steroid Sulfatase (STS) and 17ß-Hydroxysteroid Dehydrogenase Type 1 (17ß-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.
J Med Chem
; 60(9): 4086-4092, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28406629
20.
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17ß-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.
Eur J Med Chem
; 127: 944-957, 2017 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27852458