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1.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 44: 116275, 2021 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34314938
2.
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Bioorg Med Chem
; 27(13): 2905-2913, 2019 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31138459
3.
Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.
J Org Chem
; 83(6): 3126-3131, 2018 03 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29461834
4.
Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.
Chem Res Toxicol
; 27(1): 111-8, 2014 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24328261
5.
DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.
Chem Res Toxicol
; 25(1): 197-206, 2012 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22084973
6.
Water-soluble prodrugs of an Aurora kinase inhibitor.
Bioorg Med Chem Lett
; 19(5): 1409-12, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19186057
7.
Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: Synthesis of analogs designed to have improved stability to oxidative metabolism.
J Pharm Sci
; 101(9): 3486-99, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22411763
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