Detalles de la búsqueda
1.
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development.
Annu Rev Pharmacol Toxicol
; 62: 405-425, 2022 01 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34499522
2.
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model.
Xenobiotica
; 54(3): 107-115, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38193900
3.
Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug.
Drug Metab Dispos
; 51(8): 1016-1023, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37137721
4.
In Vitro Evaluation of the Reductase Activities of Human AKR1C3 Allelic Variants.
Drug Metab Dispos
; 51(9): 1188-1195, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37344179
5.
NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction.
Drug Metab Dispos
; 51(10): 1230-1237, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37349114
6.
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine.
Drug Metab Dispos
; 51(12): 1569-1577, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37722844
7.
Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver.
Drug Metab Dispos
; 51(1): 17-28, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36310032
8.
Development and Validation of a Proteomic Correlation Profiling Technique to Detect and Identify Enzymes Involved in Metabolism of Drugs of Concern.
Drug Metab Dispos
; 51(7): 824-832, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37156625
9.
Characterization of Enzymes Involved in Nintedanib Metabolism in Humans.
Drug Metab Dispos
; 51(6): 733-742, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36927840
10.
Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism.
Arch Biochem Biophys
; 736: 109536, 2023 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36724833
11.
Activation of Inflammation by MCF-7 Cells-Derived Small Extracellular Vesicles (sEV): Comparison of Three Different Isolation Methods of sEV.
Pharm Res
; 40(4): 863-871, 2023 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-36002612
12.
In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase.
J Pineal Res
; 75(1): e12870, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37002641
13.
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver.
Xenobiotica
; 53(4): 241-247, 2023 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-37305902
14.
Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota.
Drug Metab Dispos
; 50(5): 725-733, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35279645
15.
Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity.
Drug Metab Dispos
; 49(4): 322-329, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33446525
16.
Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans.
Drug Metab Dispos
; 49(9): 718-728, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34135089
17.
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver.
Xenobiotica
; 51(12): 1352-1359, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34779706
18.
Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing.
J Pharmacol Exp Ther
; 370(3): 408-415, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31270214
19.
RNA Editing Enzymes Modulate the Expression of Hepatic CYP2B6, CYP2C8, and Other Cytochrome P450 Isoforms.
Drug Metab Dispos
; 47(6): 639-647, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30988053
20.
Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences.
Drug Metab Dispos
; 47(1): 38-44, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30389729