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1.
The γ-Secretase Modulator, BMS-932481, Modulates Aß Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.
J Pharmacol Exp Ther
; 358(1): 138-50, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27189973
2.
Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.
Drug Metab Dispos
; 44(3): 320-8, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26714763
3.
Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.
Anal Chem
; 86(5): 2673-80, 2014 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24506335
4.
A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.
Biomed Chromatogr
; 26(8): 1024-32, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22623136
5.
Identifying and overcoming bioanalytical challenges associated with chlorine-containing dehydrogenation metabolites.
Rapid Commun Mass Spectrom
; 24(21): 3092-102, 2010 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20941755
6.
A validated enantioselective LC-MS/MS assay for quantification of a major chiral metabolite of an achiral 11-ß-hydroxysteroid-dehydrogenase 1 inhibitor in human plasma: Application to a clinical pharmacokinetic study.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1022: 167-172, 2016 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27100678
7.
An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies.
Bioanalysis
; 6(13): 1747-58, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24661028
8.
Dual universal peptide approach to bioanalysis of human monoclonal antibody protein drug candidates in animal studies.
Bioanalysis
; 5(11): 1363-76, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23742306
9.
A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study.
J Chromatogr B Analyt Technol Biomed Life Sci
; 926: 36-41, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23542721
10.
A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study.
J Pharm Biomed Anal
; 58: 130-5, 2012 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21982905
11.
A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma: application to a clinical pharmacokinetic study.
J Pharm Biomed Anal
; 70: 574-9, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22709607
12.
Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma.
Bioanalysis
; 4(1): 17-28, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22191591
13.
Quantitative interference by cysteine and N-acetylcysteine metabolites during the LC-MS/MS bioanalysis of a small molecule.
Drug Metab Lett
; 3(3): 181-90, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19702543
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