Detalles de la búsqueda
1.
Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.
Antimicrob Agents Chemother
; 58(11): 6861-9, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25182647
2.
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
Antimicrob Agents Chemother
; 56(6): 3359-68, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22430955
3.
Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.
Antimicrob Agents Chemother
; 56(7): 3767-75, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22526308
4.
Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
J Virol
; 85(23): 12334-42, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21957306
5.
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.
Bioorg Med Chem Lett
; 22(8): 2938-42, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22425564
6.
ß-D-2'-α-F-2'-ß-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Bioorg Med Chem Lett
; 22(18): 5924-9, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22892115
7.
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.
J Biol Chem
; 285(45): 34337-47, 2010 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-20801890
8.
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of ß-D-2'-deoxy-2'-α-fluoro-2'-ß-C-methylguanosine.
Antimicrob Agents Chemother
; 55(6): 2566-75, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21444700
9.
Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.
Bioorg Med Chem Lett
; 21(15): 4642-7, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21704526
10.
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Antimicrob Agents Chemother
; 54(8): 3187-96, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20516278
11.
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Bioorg Med Chem Lett
; 20(15): 4539-43, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20580554
12.
2'-deoxy-2'-α-fluoro-2'-ß-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Bioorg Med Chem Lett
; 20(24): 7376-80, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21050754
13.
Clevudine is efficiently phosphorylated to the active triphosphate form in primary human hepatocytes.
Antivir Ther
; 13(2): 263-9, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18505177
14.
Mechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent.
Antivir Chem Chemother
; 18(2): 83-92, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17542153
15.
Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Antivir Chem Chemother
; 17(2): 79-87, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-17042329
16.
Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.
J Med Chem
; 48(18): 5869-73, 2005 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16134952
17.
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
J Med Chem
; 48(17): 5504-8, 2005 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-16107149
18.
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
Antivir Chem Chemother
; 13(2): 115-28, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12238529
19.
Synthesis and evaluation of a novel synthetic phosphocholine lipid-AZT conjugate that double-targets wild-type and drug resistant variants of HIV.
Nucleosides Nucleotides Nucleic Acids
; 23(1-2): 385-99, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15043162
20.
Use of 2'-spirocyclic ethers in HCV nucleoside design.
J Med Chem
; 57(5): 1826-35, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24079820