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1.
Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study.
Clin Gastroenterol Hepatol
; 21(10): 2616-2628.e7, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36623678
2.
Oral tyrosine kinase 2 inhibitor PF-06826647 demonstrates efficacy and an acceptable safety profile in participants with moderate-to-severe plaque psoriasis in a phase 2b, randomized, double-blind, placebo-controlled study.
J Am Acad Dermatol
; 87(2): 333-342, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35398218
3.
Histological sub-classification of cirrhosis using collagen proportionate area in patients with chronic hepatitis C.
Liver Int
; 41(7): 1608-1613, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33894106
4.
Advantages of a wholly Bayesian approach to assessing efficacy in early drug development: a case study.
Pharm Stat
; 14(3): 205-15, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25865949
5.
Alternative Endoscopy Reading Paradigms Determine Score Reliability and Effect Size in Ulcerative Colitis.
J Crohns Colitis
; 18(1): 82-90, 2024 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37616127
6.
Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open-Label, Phase 1 Study.
J Clin Pharmacol
; 64(1): 67-79, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37691236
7.
Baseline serum and stool microbiome biomarkers predict clinical efficacy and tissue molecular response after ritlecitinib induction therapy in ulcerative colitis.
J Crohns Colitis
; 2023 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38141256
8.
Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors.
Front Med (Lausanne)
; 9: 931293, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35966871
9.
Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF-06826647: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study.
Clin Transl Sci
; 14(2): 671-682, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33290616
10.
Safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of the oral TYK2 inhibitor PF-06826647 in participants with plaque psoriasis: a phase 1, randomised, double-blind, placebo-controlled, parallel-group study.
Lancet Rheumatol
; 3(3): e204-e213, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38279383
11.
Evidence for functional ghrelin receptors on parasympathetic preganglionic neurons of micturition control pathways in the rat.
Clin Exp Pharmacol Physiol
; 37(9): 926-32, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20497419
12.
Biomarkers of Crohn's Disease to Support the Development of New Therapeutic Interventions.
Inflamm Bowel Dis
; 26(10): 1498-1508, 2020 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-32840322
13.
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
Nat Metab
; 2(10): 1135-1148, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33067605
14.
Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy.
Kidney Int Rep
; 3(6): 1316-1327, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30450458
15.
A Placebo-controlled Study of PF-06473871 (Anti-Connective Tissue Growth Factor Antisense Oligonucleotide) in Reducing Hypertrophic Skin Scarring.
Plast Reconstr Surg Glob Open
; 6(9): e1861, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-30349773
16.
A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema.
Invest Ophthalmol Vis Sci
; 59(6): 2659-2669, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29847672
17.
Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene.
Br J Pharmacol
; 143(5): 590-8, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15466445
18.
Alpha 2 Delta (α(2)δ) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome.
Front Pharmacol
; 2: 28, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21713059
19.
Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats.
Eur J Pharmacol
; 643(1): 107-12, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20598680
20.
The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation.
Adv Ther
; 26(5): 519-30, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19444393
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