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1.
Scalable Asymmetric Synthesis of the All Cis Triamino Cyclohexane Core of BMS-813160.
J Org Chem
; 87(4): 1996-2011, 2022 02 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34355895
2.
Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists.
Bioorg Med Chem Lett
; 50: 128325, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34403724
3.
Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.
Bioorg Med Chem Lett
; 30(17): 127392, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32738966
4.
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg Med Chem Lett
; 28(2): 85-93, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29233651
5.
Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.
Bioorg Med Chem Lett
; 26(2): 662-666, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26631321
6.
Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.
Bioorg Med Chem Lett
; 23(10): 3028-33, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23578688
7.
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
ACS Med Chem Lett
; 13(6): 943-948, 2022 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35707160
8.
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
J Med Chem
; 65(3): 1770-1785, 2022 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34494428
9.
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Bioorg Med Chem Lett
; 21(23): 7006-12, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22018461
10.
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.
J Med Chem
; 64(6): 3086-3099, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33689340
11.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214829
12.
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
ACS Med Chem Lett
; 10(3): 367-373, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891142
13.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem
; 62(7): 3228-3250, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30893553
14.
Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.
Bioorg Med Chem Lett
; 18(6): 1910-5, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18291644
15.
Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.
J Med Chem
; 50(13): 3015-25, 2007 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-17552509
16.
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
J Med Chem
; 59(13): 6248-64, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27309907
17.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem
; 59(19): 9173-9200, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27583770
18.
Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341).
J Med Chem
; 58(10): 4278-90, 2015 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-25905990
19.
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.
J Med Chem
; 55(13): 6162-75, 2012 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22650305
20.
One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.
J Org Chem
; 69(1): 188-91, 2004 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-14703396
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