Detalles de la búsqueda
1.
Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway.
Int J Mol Sci
; 24(11)2023 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298475
2.
Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2'-Deoxyguanosine and 2'-Substituted RNA Analogues.
Int J Mol Sci
; 24(21)2023 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37958511
3.
Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives.
Nucleic Acids Res
; 48(22): 12556-12565, 2020 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33270863
4.
Antiproliferative Effects of the Aptamer d(GGGT)4 and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells.
Int J Mol Sci
; 23(11)2022 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35682635
5.
Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction.
Int J Mol Sci
; 23(3)2022 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35163018
6.
Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads.
Int J Mol Sci
; 23(23)2022 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36499249
7.
Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG2T(G3T)3] and Its Derivatives with an Abasic Site Replacing Single Thymidine.
Int J Mol Sci
; 22(13)2021 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34208896
8.
Aptamers against the ß-Conglutin Allergen: Insights into the Behavior of the Shortest Multimeric (Intra)Molecular DNA G-Quadruplex.
Int J Mol Sci
; 22(3)2021 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33498970
9.
Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923.
Int J Mol Sci
; 21(16)2020 Aug 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32781637
10.
Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-ß-OTX2-SNAIL via PTEN inhibition.
Brain
; 141(5): 1300-1319, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29490009
11.
Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality.
Nucleic Acids Res
; 45(14): 8156-8166, 2017 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-28666330
12.
The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.
Bioorg Chem
; 76: 202-209, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29190476
13.
Backbone modified TBA analogues endowed with antiproliferative activity.
Biochim Biophys Acta Gen Subj
; 1861(5 Pt B): 1213-1221, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27663232
14.
Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.
Nucleic Acids Res
; 43(16): 7702-16, 2015 Sep 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26250112
15.
Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.
Nucleic Acids Res
; 43(22): 10602-11, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26582916
16.
The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures.
Org Biomol Chem
; 13(27): 7421-9, 2015 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25997822
17.
Expanding the potential of G-quadruplex structures: formation of a heterochiral TBA analogue.
Chembiochem
; 15(5): 652-5, 2014 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24520055
18.
5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.
Chembiochem
; 15(16): 2427-34, 2014 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25214456
19.
More than one non-canonical phosphodiester bond in the G-tract: formation of unusual parallel G-quadruplex structures.
Org Biomol Chem
; 12(3): 534-40, 2014 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24287516
20.
A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance.
Org Biomol Chem
; 12(44): 8840-3, 2014 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-25296283