Detalles de la búsqueda
1.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg Med Chem Lett
; 21(8): 2394-9, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21414779
2.
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 51(6): 1637-48, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18278858
3.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem
; 51(6): 1681-94, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18321037
4.
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Bioorg Med Chem Lett
; 18(3): 1172-6, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18083554
5.
Structural changes at synapses after delayed perfusion fixation in different regions of the mouse brain.
J Comp Neurol
; 501(5): 731-40, 2007 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-17299754
6.
Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.
J Med Chem
; 50(18): 4351-73, 2007 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-17696416
7.
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J Med Chem
; 50(4): 611-26, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17253678
8.
Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.
J Med Chem
; 50(4): 627-40, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17253679
9.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem
; 49(16): 4981-91, 2006 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16884310
10.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16970394
11.
Classification of kinase inhibitors using a Bayesian model.
J Med Chem
; 47(18): 4463-70, 2004 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-15317458
12.
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
J Med Chem
; 53(17): 6368-77, 2010 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-20684549
13.
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Neuron
; 64(6): 807-27, 2009 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20064389
14.
A quantitative analysis of kinase inhibitor selectivity.
Nat Biotechnol
; 26(1): 127-32, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18183025
15.
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Bioorg Med Chem Lett
; 17(10): 2886-9, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17350837
16.
Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold.
Bioorg Med Chem Lett
; 14(8): 1909-11, 2004 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15050625
17.
Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.
Bioorg Med Chem Lett
; 13(13): 2231-4, 2003 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-12798340
Resultados
1 -
17
de 17
1
Próxima >
>>