Detalles de la búsqueda
1.
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia.
Pharm Res
; 39(5): 837-850, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35484370
2.
Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease.
Respir Res
; 20(1): 132, 2019 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31253162
3.
Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures.
J Pharmacokinet Pharmacodyn
; 45(4): 649-658, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29948795
4.
Population pharmacokinetic and pharmacodynamic analysis of BIIB023, an anti-TNF-like weak inducer of apoptosis (anti-TWEAK) monoclonal antibody.
Br J Clin Pharmacol
; 82(1): 118-28, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26896828
5.
Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.
Br J Clin Pharmacol
; 82(1): 108-17, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27016000
6.
A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors.
Invest New Drugs
; 32(3): 518-25, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24458261
7.
Evaluation of OCT2-mediated drug-drug interactions between ulotaront and metformin in subjects with schizophrenia.
Pharmacol Res Perspect
; 12(2): e1191, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38527949
8.
Considerations for Industry-Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program.
Clin Pharmacol Ther
; 2024 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38519861
9.
Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Clin Pharmacol Ther
; 2024 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-38822554
10.
Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans.
Neurol Ther
; 12(3): 815-832, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36932300
11.
A randomized, single-dose, crossover study of the effects of ulotaront on electrocardiogram intervals in subjects with schizophrenia.
Clin Transl Sci
; 16(6): 1063-1074, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36949248
12.
A Phase I, Open-Label, Fixed Sequence Study to Investigate the Effect of Cytochrome P450 2D6 Inhibition on the Pharmacokinetics of Ulotaront in Healthy Subjects.
Clin Pharmacokinet
; 62(12): 1755-1763, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37882999
13.
A sensitive LC-MS/MS method for simultaneous quantification of ulotaront and its N-desmethyl metabolite in human plasma and application to a clinical study.
J Pharm Biomed Anal
; 207: 114404, 2022 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34700199
14.
ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies.
J Clin Pharmacol
; 62(12): 1480-1500, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35665514
15.
Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia.
CPT Pharmacometrics Syst Pharmacol
; 10(10): 1245-1254, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34292664
16.
Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson's disease.
Clin Transl Sci
; 14(4): 1464-1475, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33650272
17.
Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.
Toxicol Pathol
; 38(4): 606-18, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20448081
18.
The rate of dasotraline brain entry is slow following intravenous administration.
Psychopharmacology (Berl)
; 237(11): 3435-3446, 2020 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-32813030
19.
Industrial Perspective on the Benefits Realized From the FDA's Model-Informed Drug Development Paired Meeting Pilot Program.
Clin Pharmacol Ther
; 110(5): 1172-1175, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33991429
20.
First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica.
PLoS One
; 10(5): e0125034, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25962165