Detalles de la búsqueda
1.
Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.
Drug Metab Dispos
; 48(8): 724-734, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32482623
2.
Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans.
Xenobiotica
; 50(6): 621-629, 2020 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-31566996
3.
Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
J Pharmacol Exp Ther
; 368(1): 136-145, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30361237
4.
Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.
Drug Metab Dispos
; 47(11): 1352-1360, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31427432
5.
Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Drug Metab Dispos
; 46(2): 178-188, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29162614
6.
Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11ß-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.
Br J Clin Pharmacol
; 84(1): 130-141, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28850715
7.
Strategy for the Quantitation of a Protein Conjugate via Hybrid Immunocapture-Liquid Chromatography with Sequential HRMS and SRM-Based LC-MS/MS Analyses.
Anal Chem
; 89(9): 5144-5151, 2017 05 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28402627
8.
Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.
J Pharmacol Exp Ther
; 362(3): 385-394, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28645914
9.
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.
Drug Metab Dispos
; 45(8): 908-919, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28576766
10.
Non-cytochrome P450-mediated bioactivation and its toxicological relevance.
Drug Metab Rev
; 48(4): 473-501, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27533622
11.
Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.
Chem Res Toxicol
; 29(12): 2040-2057, 2016 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27989144
12.
Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.
Biopharm Drug Dispos
; 37(5): 276-86, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27059119
13.
High-resolution mass spectrometry-based background subtraction for identifying protein modifications in a complex biological system: detection of acetaminophen-bound microsomal proteins including argininosuccinate synthetase.
Chem Res Toxicol
; 28(4): 775-81, 2015 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25654186
14.
Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID.
Anal Chem
; 86(15): 7642-9, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25003239
15.
Ethylene Vinyl Alcohol Copolymer Nanofibrous Cation Exchange Chromatographic Membranes with a Gradient Porous Structure for Lysozyme Separation.
Polymers (Basel)
; 16(8)2024 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38675031
16.
Characterization of efflux transporters involved in distribution and disposition of apixaban.
Drug Metab Dispos
; 41(4): 827-35, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23382458
17.
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
Bioorg Med Chem Lett
; 23(1): 330-5, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23177783
18.
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.
Bioorg Med Chem Lett
; 23(13): 3914-9, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23683593
19.
Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib.
Drug Metab Dispos
; 40(1): 219-26, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21989950
20.
Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology.
Drug Metab Dispos
; 40(12): 2374-80, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22983304