Detalles de la búsqueda
1.
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.
Bioorg Med Chem Lett
; 25(3): 659-63, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25532755
2.
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem J
; 451(2): 313-28, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23398362
3.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.
Bioorg Med Chem Lett
; 22(13): 4404-9, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22633692
4.
Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists.
Bioorg Med Chem Lett
; 21(19): 6013-8, 2011 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21852130
5.
Magnetic-activated carbon composites derived from iron sludge and biological sludge for sulfonamide antibiotic removal.
Environ Sci Pollut Res Int
; 27(12): 13436-13446, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-32026366
6.
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
Bioorg Med Chem Lett
; 18(14): 4224-7, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18550369
7.
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.
Bioorg Med Chem Lett
; 18(23): 6151-5, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18954981
8.
The use of ligand-based de novo design for scaffold hopping and sidechain optimization: two case studies.
Bioorg Med Chem
; 16(1): 422-7, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17920281
9.
[Effect of hepatitis C virus core protein on cholangiocarcinoma tissues' epithelial-mesenchymal transition].
Zhonghua Wai Ke Za Zhi
; 45(21): 1491-3, 2007 Nov 01.
Artículo
en Zh
| MEDLINE | ID: mdl-18275718
10.
Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists.
Biochemistry
; 45(51): 15327-37, 2006 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17176055
11.
Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.
J Med Chem
; 49(21): 6170-6, 2006 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034124
12.
A point mutation in the human melanin concentrating hormone receptor 1 reveals an important domain for cellular trafficking.
Mol Endocrinol
; 19(10): 2579-90, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-15928315
13.
3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
J Med Chem
; 48(4): 1169-78, 2005 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15715483
14.
4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization.
J Med Chem
; 47(27): 6821-30, 2004 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15615531
15.
Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
J Med Chem
; 46(9): 1769-72, 2003 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-12699396
16.
Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.
J Med Chem
; 46(11): 2023-6, 2003 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-12747774
17.
Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.
J Med Chem
; 47(5): 1259-71, 2004 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-14971906
18.
3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
J Med Chem
; 47(14): 3483-6, 2004 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15214774
19.
Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.
ACS Med Chem Lett
; 5(12): 1313-7, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25516790
20.
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
ACS Med Chem Lett
; 5(12): 1334-9, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25516794