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1.
A novel platform for engineering blood-brain barrier-crossing bispecific biologics.
FASEB J
; 28(11): 4764-78, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25070367
2.
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
Nat Med
; 13(10): 1228-33, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17906634
3.
Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice.
J Immunol
; 185(3): 1577-83, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20585032
4.
Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.
J Pharmacol Exp Ther
; 339(2): 519-29, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21807883
5.
Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.
Bioconjug Chem
; 22(2): 200-10, 2011 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-21254764
6.
Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells.
J Biol Chem
; 284(47): 32686-94, 2009 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-19783658
7.
Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering.
Biotechnol Appl Biochem
; 57(1): 31-45, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20815818
8.
Lymphotoxin ß receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-κB activation.
Carcinogenesis
; 34(5): 1105-14, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23349015
9.
CRIPTO3, a presumed pseudogene, is expressed in cancer.
Biochem Biophys Res Commun
; 377(1): 215-20, 2008 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-18835250
10.
Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.
Protein Eng Des Sel
; 19(7): 317-24, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16682434
11.
Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment.
J Mol Biol
; 327(5): 1031-41, 2003 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12662928
12.
CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study.
Arthritis Res Ther
; 17: 234, 2015 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-26335795
13.
Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.
J Pharm Sci
; 91(2): 371-87, 2002 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-11835197
14.
In vitro and in vivo methods for assessing FcRn-mediated reverse transcytosis across the blood-brain barrier.
Methods Mol Biol
; 763: 383-401, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21874466
15.
Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4.
J Pharm Biomed Anal
; 55(1): 168-75, 2011 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21300512
16.
Development of an Fn14 agonistic antibody as an anti-tumor agent.
MAbs
; 3(4): 362-75, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21697654
17.
Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
Protein Sci
; 19(5): 954-66, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20198683
18.
Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma.
J Clin Invest
; 120(8): 2767-81, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20628202
19.
Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.
MAbs
; 1(2): 128-41, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-20061822
20.
Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo.
J Biol Chem
; 284(15): 10254-67, 2009 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19211557