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1.
Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition.
Bioorg Med Chem Lett
; 25(24): 5792-6, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26531152
2.
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.
Bioorg Med Chem Lett
; 20(18): 5434-8, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20709550
3.
Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation.
Front Immunol
; 11: 293, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32194553
4.
Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.
Acta Neuropathol Commun
; 8(1): 13, 2020 02 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32019610
5.
Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040.
Psychopharmacology (Berl)
; 201(4): 483-94, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18762914
6.
In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia.
Neuropsychopharmacology
; 33(7): 1642-52, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17728699
7.
Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain.
Brain Res
; 1149: 50-7, 2007 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17382304
8.
A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease.
Exp Gerontol
; 94: 103-107, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27979768
9.
Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator.
Br J Pharmacol
; 174(5): 370-385, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28009436
10.
Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats.
Psychopharmacology (Berl)
; 177(1-2): 1-14, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15205870
11.
Urotensin-II, a neuropeptide ligand for GPR14, induces c-fos in the rat brain.
Eur J Pharmacol
; 493(1-3): 95-8, 2004 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15189768
12.
Sub-chronic phencyclidine administration increases brain-derived neurotrophic factor in the RAT hippocampus.
Schizophr Res
; 94(1-3): 371-2, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17560767
13.
Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice.
Eur J Pharmacol
; 603(1-3): 147-9, 2009 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-19111716
14.
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models.
J Pharmacol Exp Ther
; 321(3): 1032-45, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17327487
15.
Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism.
Eur J Neurosci
; 18(6): 1706-10, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-14511349
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