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1.
Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes.
AAPS J
; 22(2): 23, 2020 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31900603
2.
Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort.
J Endocr Soc
; 4(1): bvz015, 2020 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31993549
3.
Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.
JCI Insight
; 4(24)2019 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-31852846
4.
Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial.
Endocrine
; 62(2): 371-380, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30203123
5.
The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.
Cardiovasc Ther
; 36(1)2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29078037
6.
Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin.
Cardiovasc Ther
; 36(1)2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29057618
7.
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition with Bococizumab on Lipoprotein Particles in Hypercholesterolemic Subjects.
Clin Ther
; 39(11): 2243-2259.e5, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29037448
8.
A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development.
J Clin Pharmacol
; 57(7): 855-864, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28181260
9.
Enhancement of the efficacy of an antagonist of an extracellular receptor by attachment to the surface of a biocompatible carrier.
Pharm Res
; 21(10): 1880-5, 2004 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-15553236
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