Detalles de la búsqueda
1.
Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES.
Chem Res Toxicol
; 37(2): 199-207, 2024 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38198604
2.
Formation and Properties of DNA Adducts Generated by Reactions of Abasic Sites with 1,2-Aminothiols Including Cysteamine, Cysteine Methyl Ester, and Peptides Containing N-Terminal Cysteine Residues.
Chem Res Toxicol
; 37(2): 395-406, 2024 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38181204
3.
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct.
Chem Res Toxicol
; 2024 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38743824
4.
Reconsidering the Chemical Nature of Strand Breaks Derived from Abasic Sites in Cellular DNA: Evidence for 3'-Glutathionylation.
J Am Chem Soc
; 144(23): 10471-10482, 2022 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35612610
5.
N-Methyl-N-nitrosourea Induced 3'-Glutathionylated DNA-Cleavage Products in Mammalian Cells.
Anal Chem
; 94(45): 15595-15603, 2022 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36332130
6.
Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in DNA: New Insights from a Biomimetic Nucleoside Model System.
Chem Res Toxicol
; 35(2): 203-217, 2022 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35124963
7.
Unexpected Complexity in the Products Arising from NaOH-, Heat-, Amine-, and Glycosylase-Induced Strand Cleavage at an Abasic Site in DNA.
Chem Res Toxicol
; 35(2): 218-232, 2022 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35129338
8.
Structure of a Stable Interstrand DNA Cross-Link Involving a ß-N-Glycosyl Linkage Between an N6-dA Amino Group and an Abasic Site.
Biochemistry
; 60(1): 41-52, 2021 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33382597
9.
An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3.
J Biol Chem
; 295(46): 15566-15575, 2020 11 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32878989
10.
Formation and Repair of an Interstrand DNA Cross-Link Arising from a Common Endogenous Lesion.
J Am Chem Soc
; 143(37): 15344-15357, 2021 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34516735
11.
Synthesis of DNA Duplexes Containing Site-Specific Interstrand Cross-Links via Sequential Reductive Amination Reactions Involving Diamine Linkers and Abasic Sites on Complementary Oligodeoxynucleotides.
Chem Res Toxicol
; 34(11): 2384-2391, 2021 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34694787
12.
Interstrand Cross-Link Formation Involving Reaction of a Mispaired Cytosine Residue with an Abasic Site in Duplex DNA.
Chem Res Toxicol
; 34(4): 1124-1132, 2021 04 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33784065
13.
Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1.
Arch Biochem Biophys
; 691: 108477, 2020 09 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32717224
14.
Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy.
J Inherit Metab Dis
; 43(3): 635-644, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31652343
15.
Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs.
Chem Res Toxicol
; 32(3): 348-361, 2019 03 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30817135
16.
Replication and repair of a reduced 2Î-deoxyguanosine-abasic site interstrand cross-link in human cells.
Nucleic Acids Res
; 45(11): 6486-6493, 2017 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28431012
17.
Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA.
Nucleic Acids Res
; 45(11): 6275-6283, 2017 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28531327
18.
Generation and Single-Molecule Characterization of a Sequence-Selective Covalent Cross-Link Mediated by Mechlorethamine at a C-C Mismatch in Duplex DNA for Discrimination of a Disease-Relevant Single Nucleotide Polymorphism.
Bioconjug Chem
; 29(11): 3810-3816, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30350578
19.
Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.
J Org Chem
; 83(6): 3126-3131, 2018 03 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29461834
20.
Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity.
Biochemistry
; 56(44): 5910-5919, 2017 11 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29045138