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1.
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.
Bioorg Med Chem Lett
; 30(17): 127387, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32738984
2.
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Bioorg Med Chem Lett
; 30(23): 127602, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33038544
3.
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 29(20): 126668, 2019 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31519374
4.
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.
Bioorg Med Chem Lett
; 29(15): 1974-1980, 2019 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31138472
5.
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Bioorg Med Chem Lett
; 28(21): 3446-3453, 2018 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30268701
6.
Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.
Anal Biochem
; 524: 68-75, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27665677
7.
Synthesis of ß-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.
J Org Chem
; 81(8): 3464-9, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27052958
8.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
Bioorg Med Chem Lett
; 24(5): 1437-41, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405703
9.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Bioorg Med Chem Lett
; 23(24): 6773-6, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24153205
10.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 22(16): 5303-7, 2012 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22795627
11.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
J Med Chem
; 65(15): 10419-10440, 2022 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35862732
12.
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Bioorg Med Chem Lett
; 19(3): 817-20, 2009 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19111461
13.
Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping.
Comb Chem High Throughput Screen
; 8(4): 327-39, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16101009
14.
Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
Bioorg Med Chem Lett
; 16(23): 6063-6, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16979339
15.
CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
Drug Metab Dispos
; 31(7): 870-7, 2003 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12814963
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