Detalles de la búsqueda
1.
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.
Proc Natl Acad Sci U S A
; 111(36): E3825-30, 2014 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25157130
2.
Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
J Neurosci
; 32(17): 5900-10, 2012 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22539851
3.
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
EMBO J
; 28(18): 2706-18, 2009 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-19661922
4.
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.
J Biol Chem
; 286(12): 9985-97, 2011 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21247891
5.
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.
Mol Biol Cell
; 18(6): 1979-91, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17377064
6.
Donecopride, a Swiss army knife with potential against Alzheimer's disease.
Br J Pharmacol
; 177(9): 1988-2005, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31881553
7.
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
Mol Pharmacol
; 75(4): 982-90, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19168624
8.
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
J Med Chem
; 50(15): 3585-95, 2007 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17602546
9.
Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease.
Neuropharmacology
; 126: 128-141, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28844596
10.
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
J Med Chem
; 58(7): 3172-87, 2015 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25793650
11.
Confinement but not microgravity alters NMDA NR1 receptor expression in rat inner ear ganglia.
Neuroreport
; 14(6): 887-90, 2003 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12858054
12.
Primary culture of mouse dopaminergic neurons.
J Vis Exp
; (91): e51751, 2014 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25226064
13.
Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands.
Brain Res
; 1511: 65-72, 2013 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23148949
14.
Serotonin type 4 receptor dimers.
Methods Cell Biol
; 117: 123-39, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24143975
15.
5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.
ACS Chem Neurosci
; 4(1): 130-40, 2013 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23336052
16.
Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease.
Front Aging Neurosci
; 5: 96, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24399967
17.
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
EMBO Mol Med
; 4(10): 1043-56, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23027611
18.
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis.
Mol Pharmacol
; 67(5): 1434-43, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15689570
19.
Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.
J Biol Chem
; 280(30): 27924-34, 2005 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-15919661
20.
Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.
Proc Natl Acad Sci U S A
; 99(17): 11097-102, 2002 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-12151600