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1.
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
J Med Chem
; 51(5): 1319-23, 2008 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18269228
2.
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Cancer Biol Ther
; 4(5): 538-45, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15846106
3.
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.
J Med Chem
; 53(1): 452-9, 2010 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-19928864
4.
Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.
Cancer Res
; 70(2): 621-31, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20068177
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