Detalles de la búsqueda
1.
CYP1A inhibitors: Recent progress, current challenges, and future perspectives.
Med Res Rev
; 44(1): 169-234, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37337403
2.
Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors.
Bioorg Med Chem Lett
; 107: 129776, 2024 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38692523
3.
A Carbon-Caged Rhodamine Generating Nitrosoperoxycarbonate for Photoimmunotherapy.
Angew Chem Int Ed Engl
; : e202402949, 2024 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38644342
4.
Rational Construction of a Novel Bioluminescent Substrate for Sensing the Tumor-Associated Hydrolase Notum.
Anal Chem
; 95(13): 5489-5493, 2023 04 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36962078
5.
Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening.
Anal Chem
; 95(42): 15665-15672, 2023 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37782032
6.
Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches.
J Med Virol
; 95(2): e28542, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36727647
7.
Discovery of the covalent SARS-CoV-2 Mpro inhibitors from antiviral herbs via integrating target-based high-throughput screening and chemoproteomic approaches.
J Med Virol
; 95(11): e29208, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37947293
8.
Fluorescence-Based High-Throughput Assays for Investigating Cytochrome P450 Enzyme-Mediated Drug-Drug Interactions.
Drug Metab Dispos
; 51(10): 1254-1272, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37349113
9.
Human Carboxylesterase 1A Plays a Predominant Role in Hydrolysis of the Anti-Dyslipidemia Agent Fenofibrate in Humans.
Drug Metab Dispos
; 51(11): 1490-1498, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37550069
10.
GeoDILI: A Robust and Interpretable Model for Drug-Induced Liver Injury Prediction Using Graph Neural Network-Based Molecular Geometric Representation.
Chem Res Toxicol
; 36(11): 1717-1730, 2023 11 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37839069
11.
A rationally engineered specific near-infrared fluorogenic substrate of human pancreatic lipase for functional imaging and inhibitor screening.
Analyst
; 148(10): 2225-2236, 2023 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-37092796
12.
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors.
Bioorg Med Chem Lett
; 95: 129435, 2023 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37549850
13.
An Uncertainty-Guided Deep Learning Method Facilitates Rapid Screening of CYP3A4 Inhibitors.
J Chem Inf Model
; 63(24): 7699-7710, 2023 Dec 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38055780
14.
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase.
Bioorg Med Chem
; 91: 117413, 2023 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37490786
15.
Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects.
J Nat Prod
; 86(7): 1824-1831, 2023 07 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37337963
16.
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses.
Bioorg Chem
; 130: 106264, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36395603
17.
Synthesis and biological evaluation of esculetin derivatives as potential anti-HBV agents.
Med Chem Res
; 32(5): 899-909, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37056462
18.
[Strategy and challenge of innovative drug research and development from clinically effective ingredients of traditional Chinese medicine].
Zhongguo Zhong Yao Za Zhi
; 48(7): 1705-1710, 2023 Apr.
Artículo
en Zh
| MEDLINE | ID: mdl-37282944
19.
Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging.
J Am Chem Soc
; 144(31): 14351-14362, 2022 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35905456
20.
Super-Resolution Imaging of Autophagy by a Preferred Pair of Self-Labeling Protein Tags and Fluorescent Ligands.
Anal Chem
; 94(43): 15057-15066, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36262049