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1.
Deep generative models for ligand-based de novo design applied to multi-parametric optimization.
J Comput Chem
; 43(10): 692-703, 2022 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35218219
2.
From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.
Bioorg Med Chem Lett
; 22(8): 2963-7, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22386529
3.
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Bioorg Med Chem Lett
; 22(8): 2968-72, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22437115
4.
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
J Med Chem
; 50(4): 685-95, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17243659
5.
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.
J Med Chem
; 49(7): 2210-21, 2006 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16570917
6.
Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.
Br J Pharmacol
; 145(2): 166-77, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15723089
7.
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.
J Med Chem
; 47(18): 4494-506, 2004 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-15317461
8.
Naphthyridines as novel BET family bromodomain inhibitors.
ChemMedChem
; 9(3): 580-9, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24000170
9.
Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.
Front Pharmacol
; 3: 128, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22783192
10.
Discovery and characterization of small molecule inhibitors of the BET family bromodomains.
J Med Chem
; 54(11): 3827-38, 2011 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21568322
11.
Inhibition of ALK5 signaling induces physeal dysplasia in rats.
Toxicol Pathol
; 35(2): 284-95, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17366323
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