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1.
Antibody-mediated activation of the FGFR1/Klothoß complex corrects metabolic dysfunction and alters food preference in obese humans.
Proc Natl Acad Sci U S A
; 117(46): 28992-29000, 2020 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33139537
2.
Effect of pirfenidone on gastric emptying in a rat model.
Pulm Pharmacol Ther
; 51: 41-47, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29944949
3.
Latest generation estrogen receptor degraders for the treatment of hormone receptor-positive breast cancer.
Expert Opin Investig Drugs
; 31(6): 515-529, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-34694932
4.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34251202
5.
Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies.
Regul Toxicol Pharmacol
; 54(2): 164-82, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19345250
6.
A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing.
J Pharmacol Toxicol Methods
; 94(Pt 1): 19-25, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29660397
7.
Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals.
MAbs
; 9(8): 1379-1388, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28895785
8.
Effects of RG7652, a Monoclonal Antibody Against PCSK9, on LDL-C, LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or With Established Coronary Heart Disease (from the Phase 2 EQUATOR Study).
Am J Cardiol
; 119(10): 1576-1583, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28343601
9.
Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates.
Br J Pharmacol
; 148(8): 1116-23, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16847437
10.
Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates.
Reprod Toxicol
; 63: 82-95, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27211603
11.
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/ßKlotho Complex.
EBioMedicine
; 2(7): 730-43, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288846
12.
Immunomodulation and lymphoma in humans.
J Immunotoxicol
; 11(1): 1-12, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-23746314
13.
Combined administration of RG7652, a recombinant human monoclonal antibody against PCSK9, and atorvastatin does not result in reduction of immune function.
Toxicol Sci
; 140(2): 470-80, 2014 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24848798
14.
Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab.
Mol Cancer Ther
; 13(2): 540-52, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24258345
15.
Corrigendum to 'Effects of RG7652, a Monoclonal Antibody Against PCSK9, on Low-Density Lipoprotein Cholesterol (LDL-C), LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or with Established Coronary Heart Disease (From the Phase 2 EQUATOR Study)' The American Journal of Cardiology 119 (2017) 1576-1583.
Am J Cardiol
; 122(3): 527, 2018 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29448977
16.
Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies.
MAbs
; 4(6): 724-31, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23778267
17.
Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade.
Blood
; 110(12): 3959-67, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17687108
18.
A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys.
Am J Pathol
; 168(2): 476-89, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16436662
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