Detalles de la búsqueda
1.
Design, synthesis, and biological evaluation of some new 2-phenyl-3,6-pyridazinedione derivatives as PDE-5 inhibitors.
Bioorg Chem
; 145: 107213, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38368658
2.
Exploration of thiazolidine-2,4-diones as tyrosine kinase inhibitors: Design, synthesis, ADMET, docking, and antiproliferative evaluations.
Arch Pharm (Weinheim)
; 356(3): e2200465, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36403198
3.
New quinazolinone-based derivatives as DHFR/EGFR-TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity.
Arch Pharm (Weinheim)
; 356(1): e2200417, 2023 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-36257809
4.
Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors.
Bioorg Chem
; 128: 106099, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35994884
5.
Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity.
J Enzyme Inhib Med Chem
; 37(1): 701-717, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35168458
6.
Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities.
Bioorg Chem
; 107: 104569, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33387732
7.
Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs).
Bioorg Chem
; 116: 105347, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34555628
8.
3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations.
Bioorg Chem
; 115: 105205, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34329992
9.
Design, synthesis, and pharmacological characterization of some 2-substituted-3-phenyl-quinazolin-4(3H)-one derivatives as phosphodiesterase inhibitors.
Arch Pharm (Weinheim)
; 354(9): e2100051, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-33977557
10.
Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3-dioxygenase inhibitors.
Arch Pharm (Weinheim)
; 354(11): e2100202, 2021 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-34313342
11.
Synthesis of some N-aroyl-2-oxindole benzenesulfonamide conjugates with carbonic anhydrase inhibitory activity.
Bioorg Chem
; 96: 103635, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32028060
12.
Synthesis and selective inhibitory effects of some 2-oxindole benzenesulfonamide conjugates on human carbonic anhydrase isoforms CA I, CA II, CA IX and CAXII.
Bioorg Chem
; 95: 103514, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31887473
13.
Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors.
Bioorg Chem
; 104: 104198, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32920355
14.
Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking.
Bioorg Chem
; 99: 103780, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32224337
15.
Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking.
Bioorg Chem
; 94: 103411, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31711767
16.
Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors.
Bioorg Chem
; 83: 186-197, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30380447
17.
Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity.
Arch Pharm (Weinheim)
; 352(8): e1900002, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-31353608
18.
Design and synthesis of novel imidazo[4,5-b]pyridine based compounds as potent anticancer agents with CDK9 inhibitory activity.
Bioorg Chem
; 80: 565-576, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30025343
19.
Synthesis, antitumor activity evaluation, and DNA-binding study of coumarin-based agents.
Arch Pharm (Weinheim)
; 351(1)2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-29148081
20.
Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates.
Bioorg Med Chem Lett
; 25(11): 2314-20, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25937011