Detalles de la búsqueda
1.
Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61).
Neurobiol Dis
; 187: 106298, 2023 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37716515
2.
Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin.
Toxicol Appl Pharmacol
; 479: 116712, 2023 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37820772
3.
Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.
Mov Disord
; 38(6): 1044-1055, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37050861
4.
Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells.
Int J Mol Sci
; 24(3)2023 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36768890
5.
Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Neurobiol Dis
; 152: 105297, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33581254
6.
A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia.
Epilepsia
; 62(6): 1460-1471, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33955541
7.
Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils.
Proc Natl Acad Sci U S A
; 115(41): E9590-E9599, 2018 10 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30254169
8.
A mutation map for human glycoside hydrolase genes.
Glycobiology
; 30(8): 500-515, 2020 07 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32039448
9.
Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy.
Neurobiol Dis
; 134: 104664, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31678583
10.
Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity.
J Biol Chem
; 292(26): 11070-11078, 2017 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-28522605
11.
Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients.
Biochim Biophys Acta Mol Basis Dis
; 1863(3): 817-826, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28062276
12.
A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn ("line 61") Mice.
Neurotherapeutics
; 20(1): 97-116, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36715870
13.
Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies.
NPJ Parkinsons Dis
; 9(1): 97, 2023 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37349373
14.
Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
Cells
; 11(9)2022 05 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35563868
15.
Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Neuropharmacology
; 185: 108449, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33450274
16.
Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines.
Fluids Barriers CNS
; 18(1): 36, 2021 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34344390
17.
Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain?
Pharmaceutics
; 12(10)2020 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33066604
18.
A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies.
Fluids Barriers CNS
; 17(1): 53, 2020 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32843059
19.
Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model.
Neuropharmacology
; 162: 107817, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31654704
20.
Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.
Neuropharmacology
; 180: 108297, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32890589