Detalles de la búsqueda
1.
Potentiation of the GABAAR reveals variable energetic contributions by etiocholanolone and propofol.
Biophys J
; 2023 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37752702
2.
Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor.
Mol Pharmacol
; 104(3): 115-131, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37316350
3.
The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1ß3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State.
Mol Pharmacol
; 101(2): 68-77, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34853153
4.
Multiple functional neurosteroid binding sites on GABAA receptors.
PLoS Biol
; 17(3): e3000157, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30845142
5.
Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1ß2γ2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone.
Mol Pharmacol
; 100(1): 19-31, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33958479
6.
Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABAA Receptor: Relating Occupancy to State Functions.
Mol Pharmacol
; 98(4): 303-313, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32873746
7.
Reduced Activation of the Synaptic-Type GABAA Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization.
Mol Pharmacol
; 98(6): 762-769, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32978327
8.
Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites.
Mol Pharmacol
; 98(4): 280-291, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32675382
9.
Analysis of GABAA Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites.
Mol Pharmacol
; 95(1): 70-81, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30337372
10.
Steady-State Activation and Modulation of the Concatemeric α1ß2γ2L GABAA Receptor.
Mol Pharmacol
; 96(3): 320-329, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31263018
11.
GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity.
Mol Pharmacol
; 93(2): 90-100, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29150461
12.
High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors.
Mol Pharmacol
; 93(5): 468-476, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439087
13.
Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABAA Receptors.
Mol Pharmacol
; 93(2): 178-189, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29192122
14.
The Actions of Drug Combinations on the GABAA Receptor Manifest as Curvilinear Isoboles of Additivity.
Mol Pharmacol
; 92(5): 556-563, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28790148
15.
The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4ß2 Receptors.
Mol Pharmacol
; 91(2): 100-109, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27895161
16.
Determination of the Residues in the Extracellular Domain of the Nicotinic α Subunit Required for the Actions of Physostigmine on Neuronal Nicotinic Receptors.
Mol Pharmacol
; 92(3): 318-326, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28630263
17.
Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay.
ACS Chem Neurosci
; 15(5): 909-915, 2024 03 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38386612
18.
Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABAA Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor.
Biomolecules
; 13(4)2023 04 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37189445
19.
The Mechanism of Enantioselective Neurosteroid Actions on GABAA Receptors.
Biomolecules
; 13(2)2023 02 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36830708
20.
UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
Sci Adv
; 9(44): eadh2584, 2023 11 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37910615