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1.
Amino-terminally elongated Aß peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains.
Neuropathol Appl Neurobiol
; 50(3): e12991, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38867123
2.
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Mol Psychiatry
; 26(10): 5766-5788, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32647257
3.
Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan.
Neurobiol Dis
; 158: 105452, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34298087
4.
Ion channel formation by N-terminally truncated Aß (4-42): relevance for the pathogenesis of Alzheimer's disease.
Nanomedicine
; 29: 102235, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32531337
5.
Aß truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition.
Biochim Biophys Acta Mol Basis Dis
; 1864(1): 208-225, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28711595
6.
Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Mol Psychiatry
; 26(10): 5789, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34272490
7.
Sequential Amyloid-ß Degradation by the Matrix Metalloproteases MMP-2 and MMP-9.
J Biol Chem
; 290(24): 15078-91, 2015 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25897080
8.
Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid.
Neurobiol Dis
; 85: 130-143, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26459115
9.
The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain.
Neurobiol Dis
; 86: 29-40, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26581638
10.
Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration.
Biochim Biophys Acta
; 1842(12 Pt A): 2457-67, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25261792
11.
Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid ß and the Asn23 Iowa mutation.
Biochem J
; 456(3): 347-60, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24028142
12.
Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
Am J Geriatr Psychiatry
; 21(5): 474-83, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23570890
13.
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Proc Natl Acad Sci U S A
; 107(17): 7969-74, 2010 Apr 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-20385796
14.
Microglia produce the amyloidogenic ABri peptide in familial British dementia.
bioRxiv
; 2023 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37425748
15.
Insights into caspase-mediated apoptotic pathways induced by amyloid-ß in cerebral microvascular endothelial cells.
Neurodegener Dis
; 10(1-4): 324-8, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22156599
16.
Identification of Clusterin as a Major ABri- and ADan-Binding Protein Using Affinity Chromatography.
Methods Mol Biol
; 2466: 49-60, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35585310
17.
N-terminally truncated Aß4-x proteoforms and their relevance for Alzheimer's pathophysiology.
Transl Neurodegener
; 11(1): 30, 2022 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35641972
18.
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells.
J Biol Chem
; 285(35): 27144-27158, 2010 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-20576603
19.
Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.
Glycobiology
; 21(10): 1382-8, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21752865
20.
Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.
Am J Pathol
; 176(4): 1841-54, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20228223