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1.
Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors.
Bioorg Med Chem Lett
; 26(12): 2952-2956, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27133481
2.
Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans.
Xenobiotica
; 43(12): 1027-36, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23641955
3.
Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging.
Pharmacol Res Perspect
; 9(2): e00731, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33660925
4.
Variability in Human In Vitro Enzyme Kinetics.
Methods Mol Biol
; 2342: 443-479, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34272704
5.
In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide.
J Pharm Biomed Anal
; 39(5): 1014-20, 2005 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-16023819
6.
Identification of diethylene glycol monobutyl ether as a source of contamination in an ion trap mass spectrometer.
J Am Soc Mass Spectrom
; 14(11): 1247-9, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14597114
7.
Variability in human in vitro enzyme kinetics.
Methods Mol Biol
; 1113: 337-62, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24523120
8.
Prednisone has no effect on the pharmacokinetics of CYP3A4 metabolized drugs - midazolam and odanacatib.
J Clin Pharmacol
; 54(11): 1280-9, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24895078
9.
Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates.
ACS Chem Neurosci
; 3(2): 129-40, 2012 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22860182
10.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 1: goals, properties of the PhRMA dataset, and comparison with literature datasets.
J Pharm Sci
; 100(10): 4050-73, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21523782
11.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution.
J Pharm Sci
; 100(10): 4074-89, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21452299
12.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach.
J Pharm Sci
; 100(10): 4111-26, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21480234
13.
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach.
J Pharm Sci
; 100(10): 4127-57, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21541937
14.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance.
J Pharm Sci
; 100(10): 4090-110, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21541938
15.
IgG2m4, an engineered antibody isotype with reduced Fc function.
MAbs
; 1(6): 572-9, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-20073128
16.
Effect of cytochromes P450 chemical inhibitors and monoclonal antibodies on human liver microsomal esterase activity.
Drug Metab Dispos
; 34(8): 1361-6, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16720683
17.
Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity.
Drug Metab Dispos
; 33(7): 1044-51, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15833927
18.
Pharmacokinetics of sodium borocaptate: a critical assessment of dosing paradigms for boron neutron capture therapy.
J Neurooncol
; 62(1-2): 157-69, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12749711
19.
Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR.
Drug Metab Dispos
; 31(11): 1437-47, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14570777
20.
Electrospray ionization mass spectrometry coupled to reversed-phase ion-pair high-performance liquid chromatography for quantitation of sodium borocaptate and application to pharmacokinetic analysis.
Anal Chem
; 74(10): 2394-9, 2002 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12038766
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