Detalles de la búsqueda
1.
Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions.
Br J Clin Pharmacol
; 84(9): 1941-1949, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29665130
2.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 685509, a soluble guanylyl cyclase activator, in healthy volunteers: Results from two randomized controlled trials.
Naunyn Schmiedebergs Arch Pharmacol
; 2024 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38789635
3.
Relative bioavailability and pharmacodynamic effects of methantheline compared with atropine in healthy subjects.
Eur J Clin Pharmacol
; 68(11): 1473-81, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22527350
4.
Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research.
Pharmaceutics
; 14(4)2022 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35456635
5.
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Clin Pharmacokinet
; 59(12): 1627-1639, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32504272
6.
Disposition and antimuscarinic effects of the urinary bladder spasmolytics propiverine: influence of dosage forms and circadian-time rhythms.
J Clin Pharmacol
; 48(5): 570-9, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18319360
7.
Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses.
Eur J Pharm Biopharm
; 70(2): 421-8, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18582568
8.
Oral absorption of propiverine solution and of the immediate and extended release dosage forms: influence of regioselective intestinal elimination.
Eur J Clin Pharmacol
; 64(11): 1085-92, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18626633
9.
Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail.
Eur J Drug Metab Pharmacokinet
; 43(1): 69-80, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28685495
10.
The oral, once-daily phosphodiesterase 4 inhibitor roflumilast lacks relevant pharmacokinetic interactions with inhaled budesonide.
J Clin Pharmacol
; 47(8): 1005-13, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17660483
11.
Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins.
Clin Pharmacol Ther
; 80(5): 477-85, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17112804
12.
Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans.
Clin Pharmacol Ther
; 79(3): 206-17, 2006 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-16513445
13.
Quantitative determination of nystatin in human plasma using LC-MS after inhalative administration in healthy subjects.
J Chromatogr B Analyt Technol Biomed Life Sci
; 844(1): 84-8, 2006 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16890501
14.
Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants.
J Pharm Pharmacol
; 68(4): 459-66, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-27019158
15.
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.
Clin Pharmacol Ther
; 72(5): 572-83, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12426521
16.
Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.
Clin Pharmacol Ther
; 76(3): 192-200, 2004 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-15371980
17.
CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.
Clin Pharmacol Ther
; 75(3): 213-22, 2004 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15001973
18.
Pharmacokinetic drug interactions of afatinib with rifampicin and ritonavir.
Clin Drug Investig
; 34(3): 173-82, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24399452
19.
A randomized, open-label, crossover study evaluating the effect of food on the relative bioavailability of linagliptin in healthy subjects.
Clin Ther
; 33(8): 1096-103, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21803422
20.
Effect of multiple oral doses of linagliptin on the steady-state pharmacokinetics of a combination oral contraceptive in healthy female adults: an open-label, two-period, fixed-sequence, multiple-dose study.
Clin Drug Investig
; 31(9): 643-53, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21714581