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1.
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties.
Biochem Biophys Res Commun
; 539: 42-47, 2021 02 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33421767
2.
Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol.
European J Org Chem
; 2019(22): 3581-3590, 2019 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-31680778
3.
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum.
ACS Infect Dis
; 10(3): 1000-1022, 2024 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38367280
4.
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign.
ChemMedChem
; 18(11): e202200590, 2023 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36896721
5.
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization.
Sci Rep
; 12(1): 7221, 2022 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35508530
6.
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening.
Chem Sci
; 13(36): 10686-10698, 2022 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36320685
7.
Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase.
Chem Sci
; 12(22): 7775-7785, 2021 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34168831
8.
Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.
J Med Chem
; 61(21): 9395-9409, 2018 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29873484
9.
Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin.
ChemMedChem
; 13(21): 2266-2270, 2018 11 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30178575
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