Búsqueda | Biblioteca Virtual en Salud

1.

Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).

Mazer, Norman A; Hofmann, Carsten; Lott, Dominik; Gieschke, Ronald; Klein, Gregory; Boess, Frank; Grimm, Hans Peter; Kerchner, Geoffrey A; Baudler-Klein, Monika; Smith, Janice; Doody, Rachelle S.

Alzheimers Dement ; 19(6): 2287-2297, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-36454709

2.

Mathematical Disease Progression Modeling in Type 2/3 Spinal Muscular Atrophy.

Jacqmin, Philippe; Gieschke, Ronald; Delor, Isabelle; Snoeck, Eric; Vianna, Eduardo; Vuillerot, Carole; Sanwald Ducray, Patricia.

Muscle Nerve ; 58(4): 528-535, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-29938801

3.

A drug-disease model describing the effect of oseltamivir neuraminidase inhibition on influenza virus progression.

Kamal, Mohamed A; Gieschke, Ronald; Lemenuel-Diot, Annabelle; Beauchemin, Catherine A A; Smith, Patrick F; Rayner, Craig R.

Antimicrob Agents Chemother ; 59(9): 5388-95, 2015 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-26100715

4.

A semi-mechanistic model of bone mineral density and bone turnover based on a circular model of bone remodeling.

van Schaick, Erno; Zheng, Jenny; Perez Ruixo, Juan Jose; Gieschke, Ronald; Jacqmin, Philippe.

J Pharmacokinet Pharmacodyn ; 42(4): 315-32, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-26123920

5.

Disease Modeling and Model-Based Meta-Analyses to Define a New Direction for a Phase III Program of Gantenerumab in Alzheimer's Disease.

Retout, Sylvie; Gieschke, Ronald; Serafin, Daniel; Weber, Cornelia; Frey, Nicolas; Hofmann, Carsten.

Clin Pharmacol Ther ; 111(4): 857-866, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35100444

6.

In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.

Aldea, Roxana; Grimm, Hans Peter; Gieschke, Ronald; Hofmann, Carsten; Lott, Dominik; Bullain, Szofia; Delmar, Paul; Klein, Gregory; Lyons, Marco; Piazza, Fabrizio; Carare, Roxana O; Mazer, Norman A.

Alzheimers Dement (N Y) ; 8(1): e12306, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35676943

7.

Erratum for Kamal et al., A Drug-Disease Model Describing the Effect of Oseltamivir Neuraminidase Inhibition on Influenza Virus Progression.

Kamal, Mohamed A; Gieschke, Ronald; Lemenuel-Diot, Annabelle; Beauchemin, Catherine A A; Smith, Patrick F; Rayner, Craig R.

Antimicrob Agents Chemother ; 60(3): 1953, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26921415

8.

Neuraminidase inhibitors for treatment of human and avian strain influenza: A comparative modeling study.

Dobrovolny, Hana M; Gieschke, Ronald; Davies, Brian E; Jumbe, Nelson L; Beauchemin, Catherine A A.

J Theor Biol ; 269(1): 234-44, 2011 Jan 21.

Artículo en Inglés | MEDLINE | ID: mdl-20970433

9.

Population pharmacokinetics of oseltamivir when coadministered with probenecid.

Rayner, Craig R; Chanu, Pascal; Gieschke, Ronald; Boak, Lauren M; Jonsson, E Niclas.

J Clin Pharmacol ; 48(8): 935-47, 2008 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-18524996

10.

Assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: a comprehensive review.

Toovey, Stephen; Rayner, Craig; Prinssen, Eric; Chu, Tom; Donner, Barbara; Thakrar, Bharat; Dutkowski, Regina; Hoffmann, Gerhard; Breidenbach, Alexander; Lindemann, Lothar; Carey, Ellen; Boak, Lauren; Gieschke, Ronald; Sacks, Susan; Solsky, Jonathan; Small, Ian; Reddy, David.

Drug Saf ; 31(12): 1097-114, 2008.

Artículo en Inglés | MEDLINE | ID: mdl-19026027

11.

Use of quantitative clinical pharmacology to improve early clinical development success in neurodegenerative diseases.

Geerts, Hugo; Gieschke, Ronald; Peck, Richard.

Expert Rev Clin Pharmacol ; 11(8): 789-795, 2018 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-30019953

12.

An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations.

Silber, Hanna E; Jauslin, Petra M; Frey, Nicolas; Gieschke, Ronald; Simonsson, Ulrika S H; Karlsson, Mats O.

J Clin Pharmacol ; 47(9): 1159-71, 2007 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-17766701

13.

An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics.

Jauslin, Petra M; Silber, Hanna E; Frey, Nicolas; Gieschke, Ronald; Simonsson, Ulrika S H; Jorga, Karin; Karlsson, Mats O.

J Clin Pharmacol ; 47(10): 1244-55, 2007 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-17906159

14.

Conceptual and organizational barriers to quantitative systems pharmacology modeling of pathophysiological systemic drug hypotheses.

Gieschke, Ronald; Carr, Robert.

CPT Pharmacometrics Syst Pharmacol ; 11(12): 1556-1559, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36343097

15.

A multiphase model of the dynamics of HBV infection in HBeAg-negative patients during pegylated interferon-alpha2a, lamivudine and combination therapy.

Colombatto, Piero; Civitano, Luigi; Bizzarri, Ranieri; Oliveri, Filippo; Choudhury, Somesh; Gieschke, Ronald; Bonino, Ferruccio; Brunetto, Maurizia R.

Antivir Ther ; 11(2): 197-212, 2006.

Artículo en Inglés | MEDLINE | ID: mdl-16640101

16.

Model Description Language (MDL): A Standard for Modeling and Simulation.

Smith, Mike K; Moodie, Stuart L; Bizzotto, Roberto; Blaudez, Eric; Borella, Elisa; Carrara, Letizia; Chan, Phylinda; Chenel, Marylore; Comets, Emmanuelle; Gieschke, Ronald; Harling, Kajsa; Harnisch, Lutz; Hartung, Niklas; Hooker, Andrew C; Karlsson, Mats O; Kaye, Richard; Kloft, Charlotte; Kokash, Natallia; Lavielle, Marc; Lestini, Giulia; Magni, Paolo; Mari, Andrea; Mentré, France; Muselle, Chris; Nordgren, Rikard; Nyberg, Henrik B; Parra-Guillén, Zinnia P; Pasotti, Lorenzo; Rode-Kristensen, Niels; Sardu, Maria L; Smith, Gareth R; Swat, Maciej J; Terranova, Nadia; Yngman, Gunnar; Yvon, Florent; Holford, Nick.

CPT Pharmacometrics Syst Pharmacol ; 6(10): 647-650, 2017 10.

Artículo en Inglés | MEDLINE | ID: mdl-28643440

17.

Interactive visualization and communication for increased impact of pharmacometrics.

Krause, Andreas; Gieschke, Ronald.

J Clin Pharmacol ; 50(9 Suppl): 140S-145S, 2010 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-20881227

18.

Population pharmacokinetic/pharmacodynamic model for C.E.R.A. in both ESA-naive and ESA-treated chronic kidney disease patients with renal anemia.

Chanu, Pascal; Gieschke, Ronald; Charoin, Jean-Eric; Pannier, Anne; Reigner, Bruno.

J Clin Pharmacol ; 50(5): 507-20, 2010 May.

Artículo en Inglés | MEDLINE | ID: mdl-20179322

19.

Exploring cell tropism as a possible contributor to influenza infection severity.

Dobrovolny, Hana M; Baron, Marc J; Gieschke, Ronald; Davies, Brian E; Jumbe, Nelson L; Beauchemin, Catherine A A.

PLoS One ; 5(11): e13811, 2010 Nov 23.

Artículo en Inglés | MEDLINE | ID: mdl-21124892

20.

Development of Innovative Drugs via Modeling with MATLAB : A Practical Guide

Gieschke, Ronald.

Berlin, Heidelberg; Springer Berlin Heidelberg;Imprint: Springer; 2014. 399 p.

Monografía en Inglés | Bibliografia | ID: bib-361858

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