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1.
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.
Blood
; 117(2): 591-4, 2011 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-20959606
2.
Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.
J Exp Med
; 203(2): 371-81, 2006 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16446383
3.
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals.
Blood
; 116(12): 2078-88, 2010 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-20522708
4.
PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Blood
; 116(9): 1460-8, 2010 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-20505158
5.
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).
Cancer Cell
; 1(5): 421-32, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12124172
6.
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.
Cancer Res
; 62(13): 3729-35, 2002 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12097282
7.
PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
Arterioscler Thromb Vasc Biol
; 24(4): 787-92, 2004 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15061151
8.
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic polymorphism of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
J Med Chem
; 46(23): 4910-25, 2003 Nov 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-14584942
9.
Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
J Med Chem
; 45(20): 4513-23, 2002 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-12238930
10.
Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.
J Med Chem
; 45(17): 3772-93, 2002 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12166950
11.
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives.
J Med Chem
; 45(14): 3057-66, 2002 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-12086491
12.
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Bioorg Med Chem Lett
; 13(18): 3001-4, 2003 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12941321
13.
Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor.
Bioorg Med Chem Lett
; 14(19): 4867-72, 2004 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15341941
14.
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
Blood
; 104(9): 2867-72, 2004 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15256420
15.
Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice.
Am J Pathol
; 161(4): 1395-407, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12368212
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