Detalles de la búsqueda
1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21705217
2.
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(1): 383-6, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21087862
3.
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J Med Chem
; 64(1): 677-694, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33370104
4.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214829
5.
Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.
J Pharmacol Exp Ther
; 331(2): 349-60, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19652024
6.
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19376699
7.
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Sci Transl Med
; 11(502)2019 07 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31341059
8.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem
; 62(7): 3228-3250, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30893553
9.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18072718
10.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2739-44, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18364256
11.
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Bioorg Med Chem Lett
; 18(6): 1762-7, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18313298
12.
A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice.
J Leukoc Biol
; 80(4): 897-904, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16888084
13.
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.
PLoS One
; 12(7): e0181782, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28742141
14.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem
; 60(12): 5193-5208, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28541707
15.
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
J Med Chem
; 49(23): 6819-32, 2006 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-17154512
16.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem
; 59(19): 9173-9200, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27583770
17.
5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.
J Med Chem
; 48(20): 6261-70, 2005 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16190753
18.
Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.
J Med Chem
; 46(11): 2110-6, 2003 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-12747783
19.
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
J Med Chem
; 47(25): 6283-91, 2004 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15566298
20.
Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
J Med Chem
; 53(18): 6629-39, 2010 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-20804198