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1.
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor.
Bioorg Med Chem Lett
; 66: 128728, 2022 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35413417
2.
Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19).
Bioorg Med Chem Lett
; 53: 128421, 2021 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34718128
3.
Simultaneous determination of sacubitrilat and fimasartan in rat plasma by a triple quad liquid chromatography-tandem mass spectrometry method utilizing electrospray ionization in positive mode.
Biomed Chromatogr
; 35(2): e4981, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-32895916
4.
Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor.
Bioorg Med Chem Lett
; 30(21): 127571, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32980515
5.
Relevance of preclinical rodent pharmacokinetics in the selection of a companion antibiotic for combining with beta-lactamase inhibitor.
Xenobiotica
; 50(7): 815-821, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31755347
6.
Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors.
Bioorg Med Chem Lett
; 29(11): 1313-1319, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30975623
7.
Impact of collagen-induced arthritis on the pharmacokinetic disposition of voriconazole, a widely used antifungal agent: in vitro and in vivo investigations in DBA/1J mice.
Xenobiotica
; 49(6): 698-707, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29873579
8.
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor.
Xenobiotica
; 49(10): 1164-1172, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-30488748
9.
Incurred sample reanalysis in drug discovery bioanalysis.
Biomed Chromatogr
; 33(3): e4430, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-30412644
10.
Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 28(10): 1849-1852, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29655980
11.
Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA.
Xenobiotica
; 48(1): 1-10, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28010169
12.
Preclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders.
Xenobiotica
; 48(12): 1268-1277, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29224415
13.
Review of the bioanalytical methods for the determination of methotrexate and its metabolites in in vitro, preclinical and clinical studies: Case studies and perspectives.
Biomed Chromatogr
; 31(1)2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27623319
14.
Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats.
Biomed Chromatogr
; 31(11)2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28370279
15.
ZY12201, A Potent TGR5 Agonist: Identification of a Novel Pan CYP450 Inhibitor Tool Compound for In-Vitro Assessment.
Drug Metab Lett
; 2022 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35293300
16.
Nonclinical Pharmacokinetic Evaluation of Desidustat: a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.
Eur J Drug Metab Pharmacokinet
; 47(5): 725-740, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35881329
17.
Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors.
ACS Med Chem Lett
; 11(4): 414-418, 2020 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32292543
18.
ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.
Pharmacol Res Perspect
; 8(4): e00565, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32790160
19.
Review of Clinical Pharmacokinetics of Avibactam, A Newly Approved non-ß lactam ß-lactamase Inhibitor Drug, In Combination Use With Ceftazidime.
Drug Res (Stuttg)
; 69(5): 245-255, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30296806
20.
Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies - Review of Case Studies.
Drug Metab Lett
; 13(1): 3-18, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30451124