Detalles de la búsqueda
1.
Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling.
Pharm Res
; 39(4): 677-689, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35301670
2.
Development and validation of a liquid chromatography-tandem mass spectrometry method for quantitation of indomethacin in rat plasma and its application to a pharmacokinetic study in rats.
Biomed Chromatogr
; 27(4): 496-501, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23059909
3.
LC-MS/MS-ESI method for simultaneous quantitation of metformin and repaglinidie in rat plasma and its application to pharmacokinetic study in rats.
Biomed Chromatogr
; 27(3): 356-64, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22865648
4.
Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study.
Biomed Chromatogr
; 26(1): 81-8, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21491472
5.
Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of bicalutamide in mouse plasma: application to a pharmacokinetic study.
Biomed Chromatogr
; 26(12): 1589-95, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22495777
6.
Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study.
Biomed Chromatogr
; 26(2): 247-55, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21633966
7.
Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study.
Biomed Chromatogr
; 26(12): 1464-71, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22354844
8.
Development and validation of an LC-MS/MS-ESI method for the determination of lorglumide, a CCK-1 antagonist in mouse plasma: application to a pharmacokinetic study.
Biomed Chromatogr
; 26(7): 833-8, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22052726
9.
A strategy for extending the applicability of a validated plasma calibration curve to quantitative measurements in multiple tissue homogenate samples: a case study from a rat tissue distribution study of JI-101, a triple kinase inhibitor.
Biomed Chromatogr
; 26(4): 419-24, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21877323
10.
PROTACs: Current Trends in Protein Degradation by Proteolysis-Targeting Chimeras.
BioDrugs
; 36(5): 609-623, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-36098871
11.
Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study.
Biomed Chromatogr
; 25(7): 794-800, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20872957
12.
Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of acetyl-CoA and malonyl-CoA in animal tissues.
Biomed Chromatogr
; 25(12): 1352-9, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21381064
13.
A highly sensitive LC-MS/MS method for the determination of S-raclopride in rat plasma: application to a pharmacokinetic study in rats.
Biomed Chromatogr
; 25(8): 930-7, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21154642
14.
Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis.
J Pharm Biomed Anal
; 203: 114223, 2021 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34214766
15.
A highly sensitive LC-MS/MS method for the determination of S-citalopram in rat plasma: application to a pharmacokinetic study in rats.
Biomed Chromatogr
; 24(10): 1052-8, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20352615
16.
Insights into the degradation chemistry of tazarotene, a third generation acetylenic retinoid: LC-HRMS (Orbitrap), LC-MSn and NMR characterization of its degradation products, and prediction of their physicochemical and ADMET properties.
J Pharm Biomed Anal
; 186: 113316, 2020 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32413825
17.
In vitro evaluation of reactive nature of E- and Z-guggulsterones and their metabolites in human liver microsomes using UHPLC-Orbitrap mass spectrometer.
J Pharm Biomed Anal
; 186: 113275, 2020 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32247160
18.
Characterization of Photodegradation Products of Bepotastine Besilate and In Silico Evaluation of Their Physicochemical, Absorption, Distribution, Metabolism, Excretion and Toxicity Properties.
J Pharm Sci
; 109(6): 1883-1895, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32173321
19.
Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies.
ACS Med Chem Lett
; 11(12): 2374-2381, 2020 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33335659
20.
Novel Bruton tyrosine kinase inhibitor acalabrutinib quantification by validated LC-MS/MS method: An application to pharmacokinetic study in Sprague Dawley rats.
J Pharm Biomed Anal
; 164: 509-513, 2019 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30453157