Detalles de la búsqueda
1.
First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection.
Br J Clin Pharmacol
; 87(2): 598-611, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32520410
2.
First-in-human study with ACT-539313, a novel selective orexin-1 receptor antagonist.
Br J Clin Pharmacol
; 86(7): 1377-1386, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32067262
3.
Pharmacodynamic interaction between intravenous nitroglycerin and oral sacubitril/valsartan (LCZ696) in healthy subjects.
Eur J Clin Pharmacol
; 74(9): 1121-1130, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-29974143
4.
Lixisenatide reduces postprandial hyperglycaemia via gastrostatic and insulinotropic effects.
Diabetes Metab Res Rev
; 31(6): 610-8, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25773712
5.
Effects of nilotinib on single-dose warfarin pharmacokinetics and pharmacodynamics: a randomized, single-blind, two-period crossover study in healthy subjects.
Clin Drug Investig
; 31(3): 169-79, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21184622
6.
Multiple-dose clinical pharmacology of the selective orexin-1 receptor antagonist ACT-539313.
Prog Neuropsychopharmacol Biol Psychiatry
; 108: 110166, 2021 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33159976
7.
Effect of the Phosphate Binders Sevelamer Carbonate and Calcium Acetate on the Pharmacokinetics of Roxadustat After Concomitant or Time-separated Administration in Healthy Individuals.
Clin Ther
; 43(6): 1079-1091, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33962762
8.
A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects.
Clin Drug Investig
; 40(5): 433-447, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-32222912
9.
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of the Novel Oral Human GLP-1 Analogue, Oral Semaglutide, in Healthy Subjects and Subjects with Type 2 Diabetes.
Clin Pharmacokinet
; 58(6): 781-791, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30565096
10.
Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects.
J Psychopharmacol
; 32(12): 1330-1340, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30182786
11.
No QTc Prolongation with Semaglutide: A Thorough QT Study in Healthy Subjects.
Diabetes Ther
; 9(4): 1441-1456, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29799100
12.
Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects.
Eur J Drug Metab Pharmacokinet
; 43(6): 685-692, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29752643
13.
Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects.
Clin Pharmacokinet
; 56(11): 1391-1401, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28349387
14.
An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon-like peptide-1 analogue liraglutide.
J Clin Pharmacol
; 46(6): 635-41, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16707410
15.
Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study.
Clin Toxicol (Phila)
; 44 Suppl 1: 17-28, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16990190
16.
The Hypoxia-inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat (FG-4592) and Warfarin in Healthy Volunteers: A Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction Study.
Clin Ther
; 38(4): 918-28, 2016 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26947173
17.
Effect of food on everolimus absorption: quantification in healthy subjects and a confirmatory screening in patients with renal transplants.
Pharmacotherapy
; 22(2): 154-9, 2002 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-11837553
18.
Management of hyperglycemia associated with pasireotide (SOM230): healthy volunteer study.
Diabetes Res Clin Pract
; 103(3): 458-65, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24461109
19.
Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study.
Clin Pharmacol Drug Dev
; 3(5): 388-95, 2014 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27129012
20.
A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers.
Drug Des Devel Ther
; 6: 71-9, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22573933