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1.
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.
Bioorg Med Chem
; 20(15): 4635-45, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22766219
2.
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.
Bioorg Med Chem Lett
; 18(14): 3955-8, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18586490
3.
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg Med Chem
; 16(14): 6965-75, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18541433
4.
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
J Med Chem
; 50(13): 2990-3003, 2007 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-17523610
5.
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
J Med Chem
; 53(8): 3142-53, 2010 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-20337371
6.
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
J Med Chem
; 52(2): 514-23, 2009 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-19143569
7.
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.
Bioorg Med Chem
; 15(6): 2441-52, 2007 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17258463
8.
Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Bioorg Med Chem Lett
; 16(6): 1679-85, 2006 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16403626
9.
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg Med Chem Lett
; 16(7): 2000-7, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16413780
10.
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Bioorg Med Chem Lett
; 16(13): 3424-9, 2006 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16644221
11.
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Bioorg Med Chem Lett
; 16(12): 3150-5, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16603355
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