Detalles de la búsqueda
1.
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
Mol Pharmacol
; 95(2): 169-182, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30409791
2.
Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake.
Mol Pharmacol
; 93(4): 402-415, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29339398
3.
Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption.
Mol Pharmacol
; 89(1): 118-32, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26464324
4.
Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Mol Pharmacol
; 90(5): 508-521, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27555600
5.
Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis.
Clin Immunol
; 158(1): 47-58, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25796192
6.
A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.
J Biol Chem
; 287(37): 31561-73, 2012 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22810231
7.
Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.
Mol Pharm
; 10(8): 3045-56, 2013 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-23763587
8.
The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
J Biol Chem
; 286(43): 37874-86, 2011 Oct 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21896487
9.
Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location.
Traffic
; 10(11): 1599-618, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19765263
10.
Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone.
Mol Pharmacol
; 76(2): 275-89, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19435783
11.
Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3.
J Pharmacol Exp Ther
; 329(1): 252-61, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19141712
12.
High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices.
Mol Pharmacol
; 73(1): 50-61, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17940192
13.
Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.
Mol Cell Biol
; 25(1): 78-87, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15601832
14.
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.
Pharmacogenetics
; 12(8): 591-5, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12439218
15.
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.
Diabetes
; 61(1): 187-96, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22124465
16.
Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine.
Am J Physiol Renal Physiol
; 296(4): F709-22, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19211691
17.
Cell free expression and functional reconstitution of eukaryotic drug transporters.
Biochemistry
; 47(15): 4552-64, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18361503
18.
Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.
Am J Physiol Renal Physiol
; 293(3): F767-79, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17567940
19.
Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity.
J Biol Chem
; 282(39): 28501-28513, 2007 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-17686765
20.
RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1.
Am J Physiol Renal Physiol
; 291(6): F1213-23, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16788146