Detalles de la búsqueda
1.
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Int J Mol Sci
; 24(11)2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298645
2.
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.
Handb Exp Pharmacol
; 260: 327-367, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31201557
3.
A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screens.
Methods
; 96: 12-26, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26476369
4.
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
bioRxiv
; 2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712135
5.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
bioRxiv
; 2024 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712213
6.
Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.
Lab Chip
; 23(20): 4514-4527, 2023 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37766577
7.
A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies.
Metabolites
; 12(6)2022 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35736460
8.
Human biomimetic liver microphysiology systems in drug development and precision medicine.
Nat Rev Gastroenterol Hepatol
; 18(4): 252-268, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33335282
9.
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®.
Toxicology
; 450: 152667, 2021 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33359578
10.
Drug-Drug Interaction Between Oxycodone and Diazepam by a Combined in Silico Pharmacokinetic and Pharmacodynamic Modeling Approach.
ACS Chem Neurosci
; 12(10): 1777-1790, 2021 05 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33950681
11.
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS).
Toxicology
; 448: 152651, 2021 01 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-33307106
12.
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors.
Exp Biol Med (Maywood)
; 246(22): 2420-2441, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33957803
13.
Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy.
SLAS Discov
; 25(8): 939-949, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32349647
14.
Applications of the microphysiology systems database for experimental ADME-Tox and disease models.
Lab Chip
; 20(8): 1472-1492, 2020 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32211684
15.
Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks.
Nat Commun
; 11(1): 3515, 2020 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32665557
16.
A High-Throughput Assay for DNA Replication Inhibitors Based upon Multivariate Analysis of Yeast Growth Kinetics.
SLAS Discov
; 24(6): 669-681, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30802412
17.
Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System.
Sci Rep
; 9(1): 8341, 2019 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31171849
18.
Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies.
Methods Mol Biol
; 1745: 25-46, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29476461
19.
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX.
Lab Chip
; 18(17): 2614-2631, 2018 08 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30063238
20.
Requirements, features, and performance of high content screening platforms.
Methods Mol Biol
; 356: 41-61, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-16988394