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1.
Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma.
N Engl J Med
; 385(18): 1656-1668, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34706171
2.
IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels.
Am J Respir Crit Care Med
; 208(10): 1075-1087, 2023 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37708400
3.
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
Nat Chem Biol
; 10(12): 1013-9, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25326666
4.
Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial.
Lancet Respir Med
; 9(11): 1288-1298, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34302758
5.
Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).
J Med Chem
; 59(15): 7066-74, 2016 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27355974
6.
The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer.
Mol Cancer Ther
; 14(2): 384-94, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25504634
7.
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
J Med Chem
; 58(1): 376-400, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25402320
8.
MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma.
PLoS One
; 9(1): e84319, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24465403
9.
Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.
J Med Chem
; 54(20): 7206-19, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21972823
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