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1.
1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition.
Bioorg Med Chem Lett
; 28(11): 2103-2108, 2018 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29709252
2.
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
J Med Chem
; 51(6): 1668-80, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324759
3.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
J Med Chem
; 51(6): 1649-67, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324761
4.
Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.
J Med Chem
; 51(6): 1695-705, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18311900
5.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
J Med Chem
; 60(14): 5990-6017, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28324649
6.
Direct, Regioselective N-Alkylation of 1,3-Azoles.
Org Lett
; 18(1): 16-9, 2016 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26671035
7.
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
J Med Chem
; 59(6): 2794-809, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26942860
8.
Design and preparation of a potent series of hydroxyethylamine containing ß-secretase inhibitors that demonstrate robust reduction of central ß-amyloid.
J Med Chem
; 55(21): 9009-24, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468639
9.
Design and synthesis of potent, orally efficacious hydroxyethylamine derived ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem
; 55(21): 9025-44, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468684
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