Detalles de la búsqueda
1.
A survey of renal impairment pharmacokinetic studies for new oncology drug approvals in the USA from 2010 to early 2015: a focus on development strategies and future directions.
Anticancer Drugs
; 28(7): 677-701, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28542036
2.
Efficacy and safety of vismodegib in advanced basal-cell carcinoma.
N Engl J Med
; 366(23): 2171-9, 2012 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22670903
3.
Daily dosing of vismodegib to steady state does not prolong the QTc interval in healthy volunteers.
J Cardiovasc Pharmacol
; 61(1): 83-9, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23107871
4.
Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects.
Br J Clin Pharmacol
; 74(5): 788-96, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22458643
5.
A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry.
Drug Metab Dispos
; 39(8): 1460-7, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21602311
6.
Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subjects and Adults with Attention-Deficit/Hyperactive Disorder or Fibromyalgia Pain.
Clin Pharmacokinet
; 60(1): 121-131, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32856281
7.
Leveraging innovative technology to generate drug response phenotypes for the advancement of biomarker-driven precision dosing.
Clin Transl Sci
; 14(3): 784-790, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33421282
8.
Evaluating Patients With Impaired Renal Function During Drug Development: Highlights From the 2019 US FDA Pharmaceutical Science and Clinical Pharmacology Advisory Committee Meeting.
Clin Pharmacol Ther
; 110(2): 285-288, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33411946
9.
Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme.
J Crohns Colitis
; 14(9): 1202-1213, 2020 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32161949
10.
Pharmacokinetics and safety of vismodegib in patients with advanced solid malignancies and hepatic impairment.
Cancer Chemother Pharmacol
; 80(1): 29-36, 2017 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-28523596
11.
Cloning, tissue expression, and regulation of beagle dog CYP4A genes.
Toxicol Sci
; 92(2): 356-67, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16675513
12.
A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities.
Cancer Chemother Pharmacol
; 77(3): 459-76, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26811176
13.
A clinical drug-drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib.
Cancer Chemother Pharmacol
; 78(1): 41-9, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27154174
14.
Co-administration of vismodegib with rosiglitazone or combined oral contraceptive in patients with locally advanced or metastatic solid tumors: a pharmacokinetic assessment of drug-drug interaction potential.
Cancer Chemother Pharmacol
; 71(1): 193-202, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23064958
15.
A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer.
Clin Cancer Res
; 19(1): 258-67, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23082002
16.
Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients.
Clin Cancer Res
; 19(11): 3059-67, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23553850
17.
Harmonization of Renal Function Assessment Is Needed During Early Clinical Development of Oncology Drugs.
J Clin Oncol
; 34(2): 103-4, 2016 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26628472
18.
Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 879(22): 2119-26, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21704573
19.
Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding.
Clin Cancer Res
; 17(8): 2512-20, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21300760
20.
Pharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors.
Clin Cancer Res
; 17(17): 5774-82, 2011 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21753154