Detalles de la búsqueda
1.
Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies.
Br J Clin Pharmacol
; 2024 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38880932
2.
A Phase 1B Trial in GBA1-Associated Parkinson's Disease of BIA-28-6156, a Glucocerebrosidase Activator.
Mov Disord
; 38(7): 1197-1208, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37195859
3.
A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls.
Mov Disord
; 38(5): 783-795, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36916660
4.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord
; 38(3): 386-398, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36807624
5.
Neurocognitive Effect of Biased µ-Opioid Receptor Agonist Oliceridine, a Utility Function Analysis and Comparison with Morphine.
Anesthesiology
; 139(6): 746-756, 2023 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37656771
6.
A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.
Br J Clin Pharmacol
; 89(1): 361-371, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35997713
7.
Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderly.
Br J Clin Pharmacol
; 89(12): 3606-3617, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37488930
8.
Machine Learning Techniques for Developing Remotely Monitored Central Nervous System Biomarkers Using Wearable Sensors: A Narrative Literature Review.
Sensors (Basel)
; 23(11)2023 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-37299969
9.
A Randomized Trial Assessing the Safety, Pharmacokinetics, and Efficacy During Morning Off of AZ-009.
Mov Disord
; 37(4): 790-798, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35048423
10.
A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine.
Mov Disord
; 37(7): 1416-1424, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35426173
11.
Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double-blind, placebo-controlled, cross-over study.
Br J Clin Pharmacol
; 88(6): 2926-2937, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35028950
12.
First-in-human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.
Br J Clin Pharmacol
; 88(1): 103-114, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34046921
13.
Acute response to cholinergic challenge predicts long-term response to galantamine treatment in patients with Alzheimer's disease.
Br J Clin Pharmacol
; 88(6): 2814-2829, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34964149
14.
Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation.
Exp Brain Res
; 240(2): 631-649, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34993590
15.
The impact of the global COVID-19 pandemic on the conduct of clinical trials: Return to normalcy by considering the practical impact of a structured ethical analysis.
Br J Clin Pharmacol
; 87(3): 837-844, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32668047
16.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33351971
17.
A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator.
Br J Clin Pharmacol
; 87(9): 3561-3573, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33576113
18.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33891333
19.
Safety, pharmacokinetics and pharmacodynamics of SBT-020 in patients with early stage Huntington's disease, a 2-part study.
Br J Clin Pharmacol
; 87(5): 2290-2302, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33197078
20.
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults.
Pain Med
; 22(8): 1814-1826, 2021 08 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33543763