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1.
BET bromodomain inhibitors regulate keratinocyte plasticity.
Nat Chem Biol
; 17(3): 280-290, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33462494
2.
In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.
Bioorg Med Chem Lett
; 28(20): 3404-3408, 2018 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30217415
3.
Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.
Bioorg Med Chem Lett
; 26(19): 4837-4841, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27542305
4.
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 26(19): 4729-4734, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27575470
5.
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2057-64, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26951753
6.
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Bioorg Med Chem Lett
; 23(13): 3741-8, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23726034
7.
The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.
ChemMedChem
; 17(19): e202200303, 2022 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35950546
8.
Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.
ChemMedChem
; 14(14): 1305-1314, 2019 07 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31066983
9.
Entry into a new class of protein kinase inhibitors by pseudo ring design.
Bioorg Med Chem Lett
; 18(3): 897-900, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18248988
10.
Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents.
J Med Chem
; 49(15): 4451-4, 2006 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16854049
11.
Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.
J Med Chem
; 47(20): 4810-3, 2004 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-15369383
12.
Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets.
J Bone Miner Res
; 28(4): 899-911, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23129509
13.
Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors.
PLoS One
; 8(10): e77652, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24204904
14.
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.
Cancer Discov
; 2(12): 1118-33, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23002168
15.
Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.
Cancer Discov
; 2(10): 948-59, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22874768
16.
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
J Med Chem
; 54(20): 7066-83, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21936542
17.
Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg Med Chem Lett
; 17(2): 358-62, 2007 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17095212
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