Búsqueda | Biblioteca Virtual en Salud

1.

Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

Das, Abhirup; Huang, George X; Bonkowski, Michael S; Longchamp, Alban; Li, Catherine; Schultz, Michael B; Kim, Lynn-Jee; Osborne, Brenna; Joshi, Sanket; Lu, Yuancheng; Treviño-Villarreal, Jose Humberto; Kang, Myung-Jin; Hung, Tzong-Tyng; Lee, Brendan; Williams, Eric O; Igarashi, Masaki; Mitchell, James R; Wu, Lindsay E; Turner, Nigel; Arany, Zolt; Guarente, Leonard; Sinclair, David A.

Cell ; 173(1): 74-89.e20, 2018 03 22.

Artículo en Inglés | MEDLINE | ID: mdl-29570999

2.

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.

Igarashi, Masaki; Guarente, Leonard.

Cell ; 166(2): 436-450, 2016 Jul 14.

Artículo en Inglés | MEDLINE | ID: mdl-27345368

3.

Aging research-where do we stand and where are we going?

Guarente, Leonard.

Cell ; 159(1): 15-19, 2014 Sep 25.

Artículo en Inglés | MEDLINE | ID: mdl-25259916

4.

Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

Das, Abhirup; Huang, George X; Bonkowski, Michael S; Longchamp, Alban; Li, Catherine; Schultz, Michael B; Kim, Lynn-Jee; Osborne, Brenna; Joshi, Sanket; Lu, Yuancheng; Treviño-Villarreal, Jose Humberto; Kang, Myung-Jin; Hung, Tzong-Tyng; Lee, Brendan; Williams, Eric O; Igarashi, Masaki; Mitchell, James R; Wu, Lindsay E; Turner, Nigel; Arany, Zolt; Guarente, Leonard; Sinclair, David A.

Cell ; 176(4): 944-945, 2019 Feb 07.

Artículo en Inglés | MEDLINE | ID: mdl-30735637

5.

SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging.

Chang, Hung-Chun; Guarente, Leonard.

Cell ; 153(7): 1448-60, 2013 Jun 20.

Artículo en Inglés | MEDLINE | ID: mdl-23791176

6.

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

Mouchiroud, Laurent; Houtkooper, Riekelt H; Moullan, Norman; Katsyuba, Elena; Ryu, Dongryeol; Cantó, Carles; Mottis, Adrienne; Jo, Young-Suk; Viswanathan, Mohan; Schoonjans, Kristina; Guarente, Leonard; Auwerx, Johan.

Cell ; 154(2): 430-41, 2013 Jul 18.

Artículo en Inglés | MEDLINE | ID: mdl-23870130

7.

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

Libert, Sergiy; Pointer, Kelli; Bell, Eric L; Das, Abhirup; Cohen, Dena E; Asara, John M; Kapur, Karen; Bergmann, Sven; Preisig, Martin; Otowa, Takeshi; Kendler, Kenneth S; Chen, Xiangning; Hettema, John M; van den Oord, Edwin J; Rubio, Justin P; Guarente, Leonard.

Cell ; 147(7): 1459-72, 2011 Dec 23.

Artículo en Inglés | MEDLINE | ID: mdl-22169038

8.

Forever young.

Guarente, Leonard.

Cell ; 140(2): 176-8, 2010 Jan 22.

Artículo en Inglés | MEDLINE | ID: mdl-20141830

9.

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

Donmez, Gizem; Wang, Diana; Cohen, Dena E; Guarente, Leonard.

Cell ; 142(2): 320-32, 2010 Jul 23.

Artículo en Inglés | MEDLINE | ID: mdl-20655472

10.

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial.

Dellinger, Ryan W; Holmes, Holly E; Hu-Seliger, Tina; Butt, Rodney W; Harrison, Stephen A; Mozaffarian, Dariush; Chen, Oliver; Guarente, Leonard.

Hepatology ; 78(3): 863-877, 2023 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-36082508

11.

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Nakagawa, Takashi; Lomb, David J; Haigis, Marcia C; Guarente, Leonard.

Cell ; 137(3): 560-70, 2009 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-19410549

12.

Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

Guarente, Leonard.

Cell ; 132(2): 171-6, 2008 Jan 25.

Artículo en Inglés | MEDLINE | ID: mdl-18243090

13.

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

Nakahata, Yasukazu; Kaluzova, Milota; Grimaldi, Benedetto; Sahar, Saurabh; Hirayama, Jun; Chen, Danica; Guarente, Leonard P; Sassone-Corsi, Paolo.

Cell ; 134(2): 329-40, 2008 Jul 25.

Artículo en Inglés | MEDLINE | ID: mdl-18662547

14.

The brain, sirtuins, and ageing.

Satoh, Akiko; Imai, Shin-Ichiro; Guarente, Leonard.

Nat Rev Neurosci ; 18(6): 362-374, 2017 05 18.

Artículo en Inglés | MEDLINE | ID: mdl-28515492

15.

Calorie restriction and sirtuins revisited.

Guarente, Leonard.

Genes Dev ; 27(19): 2072-85, 2013 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-24115767

16.

Nicotinamide riboside with pterostilbene (NRPT) increases NAD⁺ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI.

Simic, Petra; Vela Parada, Xavier Fernando; Parikh, Samir M; Dellinger, Ryan; Guarente, Leonard P; Rhee, Eugene P.

BMC Nephrol ; 21(1): 342, 2020 08 13.

Artículo en Inglés | MEDLINE | ID: mdl-32791973

17.

Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm.

Marinescu, Anca G; Chen, Jayson; Holmes, Holly E; Guarente, Leonard; Mendes, Odete; Morris, Mark; Dellinger, Ryan W.

Int J Toxicol ; 39(4): 307-320, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-32715855

18.

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.

Chen, Hanqing; Shen, Feng; Sherban, Alex; Nocon, Allison; Li, Yu; Wang, Hua; Xu, Ming-Jiang; Rui, Xianliang; Han, Jinyan; Jiang, Bingbing; Lee, Donghwan; Li, Na; Keyhani-Nejad, Farnaz; Fan, Jian-Gao; Liu, Feng; Kamat, Amrita; Musi, Nicolas; Guarente, Leonard; Pacher, Pal; Gao, Bin; Zang, Mengwei.

Hepatology ; 68(2): 496-514, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29457836

19.

Sirtuins and calorie restriction.

Guarente, Leonard.

Nat Rev Mol Cell Biol ; 13(4): 207, 2012 Feb 29.

Artículo en Inglés | MEDLINE | ID: mdl-22374145

20.

The SirT3 divining rod points to oxidative stress.

Bell, Eric L; Guarente, Leonard.

Mol Cell ; 42(5): 561-8, 2011 Jun 10.

Artículo en Inglés | MEDLINE | ID: mdl-21658599

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Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.

Aging research-where do we stand and where are we going?

Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging.

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

Forever young.

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial.

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

The brain, sirtuins, and ageing.

Calorie restriction and sirtuins revisited.

Nicotinamide riboside with pterostilbene (NRPT) increases NAD⁺ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI.

Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm.

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.

Sirtuins and calorie restriction.

The SirT3 divining rod points to oxidative stress.