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1.
Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System.
Int J Mol Sci
; 24(7)2023 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37047398
2.
Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro.
Arch Toxicol
; 95(10): 3341-3359, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34313809
3.
A 6-month inhalation toxicology study in Apoe-/- mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.
Arch Toxicol
; 95(5): 1805-1829, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33963423
4.
Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model.
J Appl Toxicol
; 41(10): 1598-1619, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33825214
5.
A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke.
Am J Physiol Heart Circ Physiol
; 318(3): H604-H631, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31975625
6.
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague-Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.
Arch Toxicol
; 94(6): 2179-2206, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32367274
7.
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology.
Arch Toxicol
; 93(11): 3229-3247, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31494692
8.
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols.
Inhal Toxicol
; 30(13-14): 553-567, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30849254
9.
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.
Chem Res Toxicol
; 29(8): 1252-69, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27404394
10.
In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette.
Chem Res Toxicol
; 29(1): 3-18, 2016 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26651182
11.
Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe -/- mice--a systems toxicology analysis.
Inhal Toxicol
; 28(5): 226-40, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-27027324
12.
Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke.
Regul Toxicol Pharmacol
; 81 Suppl 2: S82-S92, 2016 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-27866933
13.
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.
Regul Toxicol Pharmacol
; 81 Suppl 2: S59-S81, 2016 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-27793746
14.
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.
Regul Toxicol Pharmacol
; 81 Suppl 2: S123-S138, 2016 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-27818347
15.
A framework for in vitro systems toxicology assessment of e-liquids.
Toxicol Mech Methods
; 26(6): 389-413, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27117495
16.
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.
Inflamm Res
; 64(7): 471-86, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25962837
17.
Systems biology approach for evaluating the biological impact of environmental toxicants in vitro.
Chem Res Toxicol
; 27(3): 367-76, 2014 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24428674
18.
Blood and urine multi-omics analysis of the impact of e-vaping, smoking, and cessation: from exposome to molecular responses.
Sci Rep
; 14(1): 4286, 2024 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38383592
19.
Nicotine-mediated effects in neuronal and mouse models of synucleinopathy.
Front Neurosci
; 17: 1239009, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37719154
20.
Systems biology reveals anatabine to be an NRF2 activator.
Front Pharmacol
; 13: 1011184, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36467029