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1.
Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies.
Regul Toxicol Pharmacol
; 150: 105632, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38679316
2.
Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective.
Toxicol Pathol
; 51(6): 390-396, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38293937
3.
Anatomic and Clinical Pathology Characterization of Drug-Induced Sinusoidal Obstruction Syndrome (Veno-Occlusive Disease) in Cynomolgus Macaques.
Toxicol Pathol
; 50(1): 13-22, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34414838
4.
Toxicologic Pathology Forum: Opinion on Not Euthanizing Control Animals in the Recovery Phase of Non-Rodent Toxicology Studies.
Toxicol Pathol
; 50(8): 950-956, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36226581
5.
The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey.
Regul Toxicol Pharmacol
; 120: 104857, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33387566
6.
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors.
BMC Genomics
; 21(1): 2, 2020 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31898484
7.
Antibody-drug conjugates as targeted therapies: Are we there yet? A critical review of the current clinical landscape.
Drug Discov Today Technol
; 37: 13-22, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34895651
8.
Normal ranges and variability of novel urinary renal biomarkers in Sprague-Dawley Rats: comparison of constitutive values between males and females and across assay platforms.
Toxicol Pathol
; 42(7): 1092-104, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24670813
9.
Comparison between male and female Sprague-Dawley rats in the response of urinary biomarkers to injury induced by gentamicin.
Toxicol Pathol
; 42(7): 1105-16, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24717899
10.
Nonclinical Investigation of Cytokine Mitigation Strategies for T-cell-Engaging Bispecifics in the Cynomolgus Macaque.
J Immunother
; 47(5): 160-171, 2024 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38562119
11.
Selective inhibition of integrin αvß6 leads to rapid induction of urinary bladder tumors in cynomolgus macaques.
Toxicol Sci
; 191(2): 400-413, 2023 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36515490
12.
Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade.
Mol Cancer Ther
; 21(9): 1462-1472, 2022 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35793468
13.
Immunohistochemical identification of kidney nephron segments in the dog, rat, mouse, and cynomolgus monkey.
Toxicol Pathol
; 39(7): 1115-28, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22006284
14.
Deep Learning Approaches and Applications in Toxicologic Histopathology: Current Status and Future Perspectives.
J Pathol Inform
; 12: 42, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34881097
15.
NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Cell Rep Med
; 2(5): 100279, 2021 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34095881
16.
Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Toxicol Sci
; 176(1): 224-235, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32298455
17.
PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers.
Mol Cancer Ther
; 19(10): 2068-2078, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32747418
18.
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Clin Cancer Res
; 26(9): 2188-2202, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31996389
19.
Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors.
Clin Cancer Res
; 25(15): 4735-4748, 2019 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31085720
20.
Liver Microvascular Injury and Thrombocytopenia of Antibody-Calicheamicin Conjugates in Cynomolgus Monkeys-Mechanism and Monitoring.
Clin Cancer Res
; 23(7): 1760-1770, 2017 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27683177