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1.
Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead.
Bioorg Med Chem Lett
; 43: 128077, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33932522
2.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27914948
3.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
4.
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.
Bioorg Med Chem Lett
; 26(17): 4165-9, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27496211
5.
Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.
Bioorg Med Chem Lett
; 26(24): 5871-5876, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27856084
6.
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J Med Chem
; 65(5): 4121-4155, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35171586
7.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35261239
8.
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4457-4480, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35257579
9.
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
J Med Chem
; 64(15): 11090-11128, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34270254
10.
2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(16): 4486-90, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18672365
11.
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 891-6, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18180159
12.
Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.
ACS Med Chem Lett
; 7(12): 1082-1086, 2016 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27994742
13.
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.
ACS Med Chem Lett
; 7(3): 289-93, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985317
14.
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.
ACS Med Chem Lett
; 3(4): 337-41, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900474
15.
Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
J Med Chem
; 54(12): 4187-206, 2011 Jun 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21618986
16.
3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.
Bioorg Med Chem Lett
; 12(16): 2133-6, 2002 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12127521
17.
2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists.
Bioorg Med Chem Lett
; 13(15): 2497-500, 2003 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-12852951
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