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1.
Engineering Biocatalysts for the C-H Activation of Fatty Acids by Ancestral Sequence Reconstruction.
Angew Chem Int Ed Engl
; 63(18): e202314869, 2024 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38163289
2.
Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates.
Mol Biol Evol
; 39(6)2022 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35639613
3.
Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP).
PLoS Comput Biol
; 18(10): e1010633, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36279274
4.
Genetically programmed chiral organoborane synthesis.
Nature
; 552(7683): 132-136, 2017 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29186119
5.
Ancestral sequence reconstruction of the CYP711 family reveals functional divergence in strigolactone biosynthetic enzymes associated with gene duplication events in monocot grasses.
New Phytol
; 235(5): 1900-1912, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35644901
6.
Determinants of thermostability in the cytochrome P450 fold.
Biochim Biophys Acta Proteins Proteom
; 1866(1): 97-115, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28822812
7.
Effect of Binding on Enantioselectivity of Epoxide Hydrolase.
J Chem Inf Model
; 58(3): 630-640, 2018 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29424533
8.
Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro' approach to protein engineering.
Biochem J
; 474(1): 1-19, 2017 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28008088
9.
Learning epistatic interactions from sequence-activity data to predict enantioselectivity.
J Comput Aided Mol Des
; 31(12): 1085-1096, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29234997
10.
Simulating compatible solute biosynthesis using a metabolic flux model of the biomining acidophile, Acidithiobacillus ferrooxidans ATCC 23270.
Res Microbiol
; 175(1-2): 104115, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-37572823
11.
Toward sustainable space exploration: a roadmap for harnessing the power of microorganisms.
Nat Commun
; 14(1): 1391, 2023 03 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36944638
12.
Many pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima.
Chembiochem
; 13(7): 1060-6, 2012 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22522601
13.
Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary pathways.
Chembiochem
; 12(16): 2502-10, 2011 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-21913300
14.
Potential of Acidithiobacillus ferrooxidans to Grow on and Bioleach Metals from Mars and Lunar Regolith Simulants under Simulated Microgravity Conditions.
Microorganisms
; 9(12)2021 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34946018
15.
Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods.
J Am Chem Soc
; 132(26): 9144-52, 2010 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-20536132
16.
Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates.
Appl Microbiol Biotechnol
; 81(2): 387-97, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18820909
17.
In a quest for engineering acidophiles for biomining applications: challenges and opportunities.
Genes (Basel)
; 9(2)2018 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-29466321
18.
Computational tools for directed evolution: a comparison of prospective and retrospective strategies.
Methods Mol Biol
; 1179: 315-33, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25055787
19.
Increasing the stability of an enzyme toward hostile organic solvents by directed evolution based on iterative saturation mutagenesis using the B-FIT method.
Chem Commun (Camb)
; 46(45): 8657-8, 2010 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-20957255
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